Oxidized Phosphatidylserine: Production and Bioactivities

Recent development of analytical methods for lipid hydroperoxides and preparation of highly pure lipid hydroperoxideshave revealed the important new pathophysiological roles of oxidized phospholipids. Generation of reactive oxygen speciesand subsequent oxidative stress leads to random oxidation of membrane phospholipids. However, recent studies havereported that anionic phospholipid molecules such as phosphatidylserine (PS) and cardiolipin are preferentiallyoxidized during apoptosis, resulting in efficient apoptosis execution and apoptotic cell clearance by phagocytes.This review is exclusively focused on selective production of oxidized PS (oxPS) during apoptosis as well as the novelroles of oxPS under pathophysiological conditions.