血清脑硫脂与2型糖尿病的相关性研究

目的探讨脑硫脂与2型糖尿病的关系及可能的作用机制。方法测定54例2型糖尿病患者身高、体重、腰围及血压，检测血糖、血脂、真胰岛素及脑硫脂；另设健康对照组48例。结果糖尿病组空腹血糖、胰岛素抵抗指数（HOMA—IR）水平高于对照组（t=9．216，4．609；P〈0．05），脑硫脂水平低于对照组（t=12．116，P〈0．05）；HOMA—IR与体重指数、腰围、收缩压、空腹血糖、高密度脂蛋白胆固醇（HDL—C）和真胰岛素存在单变量相关（r值分别为0．348，0．419，0．368，0．539，-0．533，0．757）；脑硫脂与体重指数、腰围、收缩压、舒张压、空腹血糖、HDL-C和HOMA—IR存在单变量相关（r值分别为-0．326，-0．363，-0．414，-0．342，-0．676，0．430，-0．566）；行多元线性回归显示，脑硫脂（β=-48．651，P=0．000），性别（β=-0．933，P=0．002），腰围（β=0．033，P=0．042）为HOMA—IR的独立危险因素。结论2型糖尿病患者血清脑硫脂降低，血清脑硫脂与糖尿病、胰岛素抵抗之间有密切的相关性，在糖尿病的发生、发展中可能起重要作用。

Relationship between serum sulfatide and type 2 diabetes mellitus

Objective To evaluate the role of sulfatide in the pathogenesis of type 2 diabetes mellitus. Methods A total of 54 patients with type 2 diabetes mellitus and 48 normal controls were enrolled in this investigation. For all the participants, height, body weight, waist circumference, and blood pressure were measured. Blood samples were collected for the testing of fasting plasma glucose, serum lipid profile, true insulin and sulfatide level. Results For the type 2 diabetes mellitus group, the levels of fasting plasma glucose, homeostasis model assessment insulin resistance （HOMA-IR）, and sulfatide were significantly higher than those of the control group （t = 9. 216, 4. 609, and 12. 116, respectively; all P 〈 0.05）. HOMA-IR was positively correlated with body mass index, waist circumference, systolic blood pressure, fasting plasma glucose, and true insulin （ r =0. 348, 0. 419, 0. 368, 0. 539, and 0. 757, respectively） , and negatively correlated with high-density lipoprotein cholesterol （HDL-C） （ r = - 0. 533）. However, sulfatide showed positive relationship with HDL-C （r = 0. 430） , and negative correlation with body mass index, waist circumference, systolic blood pressure, diastolic blood pressure, fasting plasma glucose, and true insulin （r= -0.326, -0.363, -0.414, -0.342, -0.676, and -0.566, respectively）. In muhiple linear regression analysis, sulfatide （ β = - 48. 651, P = 0. 000）, gender （β= - 0. 933, P = 0. 002）, and waist circumference （ β = 0. 033, P = 0. 042） were independent predictors for HOMA-IR. Conclusions These data show a closer relationship between serurn sulfatide and insulin resistance in type 2 diabetes mellitus patients. Serum sulfatide may play an important role in the development of type 2 diabetes mellitus.