血清特种蛋白增高患者前清蛋白浓度变化及临床意义

目的探讨血清抗链球菌溶血素＂O＂（ASO）、C反应蛋白（CRP）、人免疫球蛋白E（IgE）及类风湿因子（RF）增高与前清蛋白（PA）浓度的变化,比较其与PA的相关性,分析其临床意义。方法选择血清ASO、CRP、IgE、RF增高者及健康体检者血清,分为健康对照组和实验组,用Beckman-counlter LX20全自动生化分析仪测定其PA,分析各组与PA的关系,比较各组间的差异。结果各实验组PA值与健康对照组相比均显著降低;实验组仅CRP,升高组中CRP与PA有相关性（r=-0.49,P〈0.05）。30例ASO升高者中,PA下降者10例,占33.3%;30例CRP增高标本中,PA下降18例,占60%;30例IgE升高者中PA下降者14例,占46.7%;24例RF升高者中PA下降者16例,占53.3%。结论 ASO、CRP、IgE、RF增高患者血清PA均有下降。PA浓度与CRP含量呈负相关性,与ASO、IgE、RF无相关性。血清PA下降原因可能与其相关疾病及肝脏合成PA水平相关。

Concentration change of preaibumin in patients with elevated serum specific proteins and its clinical significance

Objective To investigate the concentration change of elevated serum ASO,CRP,IgE,RF and pre- albumin（PA） ,and to compare their correlation with PA and to analyze its clinical significance. Methods Sera of the subjects with elevated ASO,CRP,IgE and RF and healthy controls with physical examination were collected and di- vided into the normal group and the experimental group. PA was detected by the Beckmawcounlter LX20 automatic biochemical analyzer, the relationship between PA with ASO, CRP, IgE and RF was analyzed for comparing the differences among various groups. Results The PA value in each experimental group was significantly reduced corn paring with the healthy control group. In the experimental group,only CRP and CRP in the elevated group were cot related with PA （r =- 0. 49,P〈0. 05）. In 30 cases of elevated ASO,PA was decreased in 10 cases,accounting for 33.3%; 30 cases of elevated CRP samples,PA was decreased in 18 cases,accounting for 60%; 30 cases of elevated IgE, PA was declined in 14 cases,accounting for 46.7%, 24 cases of increased RF, PA was declined in 16 cases,ae counting for 53.3%. Conclusion Serum PA is decreased in the patients with increased ASO,CRP,IgE,RF. The PA concentration is negatively correlated with CRP and has no correlation with the ASO, IgE and RF. The reasons for the decline of serum PA is possibly related with the relative diseases and the level of the hepatic synthesis of PA.