胃癌患者血清Chemerin水平的测定及临床意义

目的观察胃癌患者血清Chemerin的水平变化,并探讨其与胃癌临床病理特征的关系。方法共纳入胃癌组121例及健康对照组86例。用酶联免疫吸附试验（ELISA）测量每组患者的血清Chemerin水平。结果胃癌组患者血清Chemerin水平明显高于健康对照组[（1 879.51±262.65）与（1 135.28±152.72）ng/L],差异有统计学意义（P〈0.01）。血清Chemerin水平随着胃癌TNM分级的增加而升高并与TNM分级呈显著正相关（r=0.258,P〈0.05）。结论胃癌患者血清Chemerin水平显著升高且升高程度与肿瘤的TNM分级相关,Chemerin可能成为诊断胃癌发病及预测胃癌进展程度的重要血清学标记物。

Detection of serum Chemerin levels and its clinical significance in patients with gastric cancer

Objective To investigate the change of serum Chemerin levels and its relation with clinicopathological characteristics in the patients with gastric cancer.Methods 121 patients with gastric cancer（n=121） and 86 healthy controls（n=86） were included in this cross-sectional study.Serum Chemerin levels were measured using enzyme-linked immunosorbent assay（ELISA） kit.Results Serum Chemerin levels were significantly higher in the gastric cancer group than in healthy control group with statistical difference between them[（1 879.51±262.65）vs（1 135.28±152.72）ng/L,P0.01].Serum Chemerin levels were increased with clinical TNM stage of gastric cancer and showed significantly positive correlation with clinical TNM stage（r=0.258,P0.05）.Conclusion In the patients with gastric cancer,serum Chemerin level is significantly increased and related with clinical TNM stage.Chemerin might serve as a biochemical marker for diagnosing the occurrence of gastric cancer and predicting its progression.