盐酸替罗非班对不稳定型心绞痛患者在冠脉介入治疗中TIMI血流的影响

目的：探讨不稳定型心绞痛（UA）患者经皮冠状动脉介入治疗（PCI）过程中使用血小板膜糖蛋白（GP）Ⅱb／Ⅲa受体拮抗剂盐酸替罗非班，对UA患者冠脉介入术中TIMI血流的影响。方法：选择兰州市第一人民医院2006年5月至2008年12月UA患者符合介入治疗条件并行经皮冠脉介入治疗的患者80例，其中男性54例，女性26例，平均年龄（58．3±7．8）岁。随机分成实验组（使用盐酸替罗非班＋PCI．n=43）与对照组（直接PCI．n=37），收集所有病例的临床和冠状动脉造影（CAG）资料，对比两组患者PCI术中血流TIMI分级情况。结果：实验组慢血流的发生明显低于对照组（2．33％：16．22％P〈0．05）。结论：UA介入治疗中使用盐酸替罗非班可以明显改善相关血管的前向血流。

The influence of TIMI flow in patients with unstable angina pectoris treated with tirofiban hydrochloride before PCI

Objective： To study the fluence of TIMI flow in patients with unstable angina pectoris（UA） by using intracoronary tirofiban hydrocldoride before PCI. Methods ：80 cases with unstable angina pectoris （54 males, 26 females, mean ageS8.3 ＋ 7.8 years old）were admitted from May 2006 to Dec 2008, which were devided into tirofiban hydrechloride injection group （ using intracoronary tirofiban hydrochlo- ride before PCI, n = 43 ） and PCI group （ only PCI, n = 37 ）. All patients basic clinical characteristics and CAG results were collected in which TIMI flow grades were compared in two group. Results： The slow - flow and no - reflow of the intraeoronary tirofiban injection ＋ PCI group was lower than that of the PCI group （2.33% VS 16.22%, P 〈 0.05 ）. Conclusion： Intracoronary tirofiban injection before PCI in pa- tients with UA is feasible, which can obviously improve forward flow of related blood vessel .