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| 吉西他滨联合顺铂治疗复发转移性乳腺癌临床观察 | |
| 引用本文： | 韩正全,郑荣生. 吉西他滨联合顺铂治疗复发转移性乳腺癌临床观察[J]. 实用全科医学, 2011, 9(6): 866-867 |
| 作者姓名： | 韩正全 郑荣生 |
| 作者单位： | 安徽省蚌埠医学院第一附属医院肿瘤内科,233004 |
| 摘 要： | 目的观察吉西他滨联合顺铂治疗紫杉类及蒽环类耐药的晚期乳腺癌的疗效及不良反应。方法 32例晚期乳腺癌患者采用吉西他滨800～1000 mg/m2,静脉滴注30 min,d1,8;顺铂30 mg,d2～5。21 d为一周期,治疗2个周期以上后评价疗效及不良反应。结果 32例均可评价疗效,完全缓解（CR）2例,部分缓解（PR）13例,稳定（SD）9例,进展（PD）8例,总有效率（CR＋PR）46.88%,疾病控制率（CR＋PR＋SD）75.00%。主要不良反应为骨髓抑制、胃肠道反应。结论吉西他滨联合顺铂治疗晚期乳腺癌疗效较好,不良反应轻,耐受性好,是对耐药的晚期乳腺癌的有效治疗方案之一。 |
| 关 键 词： | 吉西他滨 顺铂 乳腺癌 耐药 |
Clinical Observation of 32 Patients with Advanced Breast Cancer Treated with Gemcitabine Combined with Cisplatin |
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| HAN Zheng-quan,ZHENG Rong-sheng. Clinical Observation of 32 Patients with Advanced Breast Cancer Treated with Gemcitabine Combined with Cisplatin[J]. Applied Journal Of General Practice, 2011, 9(6): 866-867 | |
| Authors: | HAN Zheng-quan ZHENG Rong-sheng |
| Affiliation: | HAN Zheng-quan,ZHENG Rong-sheng.Department of Medical Oncology,the First Affiliated Hospital of Bengbu Medical College,Bengbu 233004,Anhui,China |
| Abstract: | Objective To study the efficacy and toxic effects of gemcitabine combined with cisplatin in treatment of the anthracycline and taxane-resistant metastatic breast cancer.Methods Thirty two patients with advanced breast cancer were treated with gemcitabine 800-1000 mg/m2 on day1 and day8,cisplatin 30 mg on days 2-5.The chemotherapy repeated every 3 weeks.Efficacy and toxic reactions were reviewed after 2 cycles of chemotherapy.Results All patients were evaluable for response:CR 2 cases,PR 13 cases,SD 9 cases,... |
| Keywords: | Gemcitabine Cisplatin Breast cancer Drug resistance |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |