首页 | 本学科首页   官方微博 | 高级检索  
     


Complete Clinical Remission of Psoriasis 6 Months After Renal Transplantation
Authors:C. Mele  M.P. Salerno  J. Romagnoli  C. De Simone  M. Castriota  F. Citterio
Affiliation:1. Department of Surgical Science, Renal Transplantation Unit, Catholic University, Rome, Italy;2. Division of Dermatology, Catholic University, Rome, Italy
Abstract:

Background

Psoriasis, one of the most common immune-mediated inflammatory diseases of the skin is mediated by activated effector T cells.

Case Report

We report a case of a 56-year-old white man with a 22-year history of severe psoriasis vulgaris with plaque and joint involvement, who experienced a complete clinical remission after renal transplantation. The patient had been on hemodialysis for 6 years because of chronic renal failure caused by an undetermined chronic nephropathy. Psoriasis, which worsened over the years, was symmetrically distributed as erythematous scaly plaques that had increased until they covered about 50% of the body surface, involving mainly the abdomen, legs, back, and arms. The patient also complained of severe itching an responsive to drugs. He had been treated with topical and systemic corticosteroids and phototherapy several times without benefit. After renal transplantation he underwent immunosuppressive therapy with corticosteroids, mycophenolate mofetil (MMF), and tacrolimus (Advagraf, beginning starting dose 1 mg/kg/day, C0 10 ng/mL).

Results

From the early days post-surgery the patient reported a fast improvement in the itching with progressive reduction of the skin lesions. After 4 months follow-up the psoriasis had completely regressed, presumably due to the immunosuppressive regimen.

Conclusion

This finding suggests that systemic immunosuppressive drugs may be useful for psoriasis an responsive to conventional therapy.
Keywords:
本文献已被 ScienceDirect 等数据库收录!
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号