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| 盐酸维拉帕米脉冲释放片体内外释药特性 | |
| 引用本文： | 范辉,周晗瑛,梁文权. 盐酸维拉帕米脉冲释放片体内外释药特性[J]. 中国医院药学杂志, 2002, 22(5): 271-274 |
| 作者姓名： | 范辉 周晗瑛 梁文权 |
| 作者单位： | 1. 浙江医科大学附属邵逸夫医院,浙江,杭州,310016 2. 浙江大学药学院,浙江,杭州,310006 |
| 摘 要： | 目的：研究盐酸维拉帕米脉冲释放片体内外释药特性。方法：用干法压制包衣技术制备盐酸维拉帕米脉冲释放片，调整包衣中致孔剂用量，通过体外释放度试验考查时滞，并用HPLC法测定家兔血药浓度，考查体内外时滞的相关性。结果：体内外时滞基本相符。结论：可用体外时滞预测体内的时滞。 |
| 关 键 词： | 盐酸维拉帕米脉冲释放片 体内外释药特性 干压包衣片 时滞 心血管系统药 |
| 文章编号： | 1001-5213(2002)05-0271-04 |
| 修稿时间： | 2001-08-29 |
Study on the in vitro and in vivo drug release of verapamil hydrochroride pulsatile release tablet |
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| FAN Hui,ZHOU Han Ying,LIANG Wen Quan. Study on the in vitro and in vivo drug release of verapamil hydrochroride pulsatile release tablet[J]. Chinese Journal of Hospital Pharmacy, 2002, 22(5): 271-274 | |
| Authors: | FAN Hui ZHOU Han Ying LIANG Wen Quan |
| Abstract: | OBJECTIVE To study the in vitro and in vivo drug release of verapamil hydrochloride pulsatile release tablet.METHODS Verapamil hydrochroride pulsatile release tablet was prepared using convenient dry coating techniques. A high performance liquid chromatography method was used to determine the plasma concentration of rabbits. The in vitro in vivo correlation was evaluated.RESULTS There was a good correlation between in vitro and in vivo lag time.CONCLUSIONS The in vivo lag time can be well predicated by in vitro value. |
| Keywords: | verapamil hydrochloride pulsatile release system dry coated tablet lag time controlled release |
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