| 序贯法测定复合靶控输注丙泊酚时瑞芬太尼抑制帕金森病患者气管插管心血管反应的EC50 |
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| 引用本文： | 许小平,王嘉锋,余喜亚,杨涛,李金宝,邓小明. 序贯法测定复合靶控输注丙泊酚时瑞芬太尼抑制帕金森病患者气管插管心血管反应的EC50[J]. 第二军医大学学报, 2013, 34(8): 868-873 |
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| 作者姓名： | 许小平 王嘉锋 余喜亚 杨涛 李金宝 邓小明 |
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| 作者单位： | 第二军医大学长海医院麻醉科,上海,200433 |
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| 摘 要： | 目的探讨复合靶控输注(TCI)丙泊酚时瑞芬太尼抑制帕金森病患者气管插管心血管反应的半数有效效应室靶浓度(EC50)。方法采用11配对病例对照研究方法,选择拟择期在全麻下行外科手术治疗的帕金森病患者31例,同时按照11配对的原则在同期住院的非帕金森病患者中选择对照31例,匹配条件为:同性别、年龄±3岁。两组患者均采用TCI丙泊酚和瑞芬太尼行麻醉诱导,设定丙泊酚效应室靶浓度为3μg/mL,瑞芬太尼效应室靶浓度采用改良序贯法确定,两组第1例患者瑞芬太尼的效应室靶浓度均为3ng/mL,相邻靶浓度之差为0.2ng/mL,以心率或收缩压变化幅度超过基础状态15%作为心血管反应阳性的判断标准。结果所有患者均未见胸壁强直,术后随访两组患者均未发生术中知晓。瑞芬太尼复合TCI丙泊酚抑制帕金森病患者气管插管时心血管反应的EC50为2.20ng/mL(95%CI:1.86～2.60ng/mL),而非帕金森病患者为2.93ng/mL(95%CI:2.72～3.15ng/mL),两者差异有统计学意义。结论复合TCI丙泊酚3μg/mL全麻诱导时,瑞芬太尼抑制帕金森病患者气管插管时心血管反应的EC50值小于非帕金森病患者。
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| 关 键 词： | 帕金森病 瑞芬太尼 半数有效效应室靶浓度 丙泊酚 心血管反应 |
| 收稿时间： | 2013-03-09 |
| 修稿时间： | 2013-07-02 |
Up-and-down sequential method in determining median effective effect-site concentration (EC50) of remifentanil required for inhibiting intubation-induced hemodynamic responses in patients with Parkinson's disease during target-controlled infusion of propo |
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| XU Xiao-ping,WANG Jia-feng,YU Xi-y,YANG Tao,LI Jin-bao and DENG Xiao-ming. Up-and-down sequential method in determining median effective effect-site concentration (EC50) of remifentanil required for inhibiting intubation-induced hemodynamic responses in patients with Parkinson's disease during target-controlled infusion of propo[J]. Former Academic Journal of Second Military Medical University, 2013, 34(8): 868-873 |
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| Authors: | XU Xiao-ping WANG Jia-feng YU Xi-y YANG Tao LI Jin-bao DENG Xiao-ming |
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| Affiliation: | Department of Anesthesiology, Changhai Hospital, Second Military Medical University, Shanghai 200433, China*Corresponding author. |
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| Abstract: | |
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| Keywords: | Parkinson disease remifentanil EC50 propofol hemodynamic responses |
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