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| 胎儿宫内生长迟缓的实验动物模型 | |
| 引用本文： | 陈光亮,张蕾,王钦茂. 胎儿宫内生长迟缓的实验动物模型[J]. 中国药理学通报, 2001, 17(1): 108-110 |
| 作者姓名： | 陈光亮 张蕾 王钦茂 |
| 作者单位： | 1. 安徽中医学院药理学教研室, 2. 安徽省立医院药剂科, |
| 摘 要： | 目的 建立胎儿宫内生长迟缓的实验动物模型及观测指标。方法 妊娠动物被动吸烟、被动吸烟 +饮酒、注射亚硝基左旋精氨酸甲酯、注射更生霉素、维生素B1缺乏饮食+抗硫胺素、结扎子宫动脉等。结果 胎仔体重降低、身长短小 ,幼仔体格及神经系统发育缓慢 ,母体体重降低、血液营养物质和胎盘血流减少 ,胎盘组织细胞结构和功能发等。结论 上述方法可以建立胎儿宫内生长迟缓动物模型 |
| 关 键 词： | 动物模型 胎儿宫内生长迟缓 被动吸烟 一氧化氮合成酶抑制剂 |
| 文章编号： | 1001-1978(2001)01-0108-03 |
| 修稿时间： | 2000-04-18 |
The experimental animal models of intrauterine growth retardation |
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| CHEN Guang-Liang,ZHANG Lei,WANG Qin-mao. The experimental animal models of intrauterine growth retardation[J]. Chinese Pharmacological Bulletin, 2001, 17(1): 108-110 | |
| Authors: | CHEN Guang-Liang ZHANG Lei WANG Qin-mao |
| Affiliation: | CHEN Guang Liang,ZHANG Lei 1,WANG Qin Mao |
| Abstract: | AIM This paper was to review the methods of establishing experimental animal models of intrauterine growth retardation (IUGR) and their observed index. METHODS Passive smoking, passive smoking plus drinking wine, N G nitro L arginine methyl ester, dactinomycin, thiamine deficiency plus pyrithiamine, or ligating the uterine artery during pregnancy were used.RESULT The fatal and maternal body weight was lower body length; was shorter; infant physique and nerve system development was slow.CONCLUSION The above methods could establish animal models of IUGR. |
| Keywords: | animal model intrauterine growth retardation passive smoking nitric oxide synthesis inhibitor |
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