| 贝那普利与缬沙坦治疗慢性肾病蛋白尿及高血压 |
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| 引用本文： | 范星,兰天飙,王旭. 贝那普利与缬沙坦治疗慢性肾病蛋白尿及高血压[J]. 药物流行病学杂志, 2008, 17(5) |
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| 作者姓名： | 范星 兰天飙 王旭 |
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| 作者单位： | 广州军区武汉总医院肾脏病科,武汉,4301370 |
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| 摘 要： | 目的:观察贝那普利与缬沙坦单用及联用治疗慢性肾脏病患者蛋白尿及高血压的临床疗效和安全性.方法:75例慢性肾病合并高血压患者随机分为贝那普利组(n=28)、缬沙坦组(n=26)、贝那普利与缬沙坦联用组(n=21),观察治疗前、治疗第4周和第8周的血压、24 h蛋白尿定量、血尿素氮(BUN)、血清肌酐(SCr)和血尿素(SUA)等指标.结果:三组患者治疗后血压和24 h蛋白尿定量较治疗前明显下降(P<0.01),且联用组较缬沙坦组和贝那普利组降蛋白尿作用更显著(P<0.05).三组患者治疗前后BUN,Scr无明显变化,但缬沙坦组及联用组治疗后SUA较治疗前明显下降(P<0.05).结论:贝那普利与缬沙坦联用对慢性肾脏病合并高血压患者具有良好的降蛋白尿和降压作用.
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| 关 键 词： | 贝那普利 缬沙坦 慢性肾病 高血压 蛋白尿 |
Therapeutic Effect of Benazepril Combination with Valsartan in Treatment of Chronic Kidney Patients with Proteinuria and Hypertension |
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| Fan Xing,Lan Tianbiao,Wang Xu. Therapeutic Effect of Benazepril Combination with Valsartan in Treatment of Chronic Kidney Patients with Proteinuria and Hypertension[J]. Chinese Journal of Pharmacoepidemiology, 2008, 17(5) |
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| Authors: | Fan Xing Lan Tianbiao Wang Xu |
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| Affiliation: | Fan Xing,Lan Tianbiao,Wang Xu Department of Nephrology,Wuhan General Hospital of Guangzhou Comm,,Wuhan 430070,China |
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| Abstract: | Objective:To evaluate the clinical efficacy of benazepril in combination with valsartan in treating chronic kidney patients with proteinuria and hypertension.Method:75 chronic kidney patients were divided into benazepril group(n=28)and valsartan group(n=26)and combination treatment group(n=21).The changes of 24 hours urinary protein excretion and blood pressure and serum BUN and SCr were observed before the treatment and 4 and 8 weeks after it. Result:The 24 hours urinary protein excretion and blood pressur... |
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| Keywords: | Benazepril Valsartan Hypertension Proteinuria |
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