抗炎免疫药理实验方法学的某些进展

抗炎免疫药物多作用于炎症免疫过程的不同环节，受到机体神经内分泌系统内环境的相互影响，而且不同品种、性别年龄的动物或同一动物的不同病理模型对抗炎免疫药物的反应可能不同。因此，在进行抗炎免疫药物研究时，选择合理的实验方法尤为重要。综述了近年来抗炎免疫药理学整体动物模型研究的某些进展，为抗炎免疫药物的药理学研究和炎症免疫性疾病的治疗提供新的思路。

Some Progress of Intact Animal Model in Antiinflammatory-immunomodulating Pharmacology

To elucidate the importance of intact animal model in pharmacological study of antiinflammatory immunomodulating drugs (AIIDs), some progress of intact animal models in antiinflammatory immunomodulating pharmacology were reviewed, such as animal model of adjuvant arthritis, systemic lupus erythematosus, immunological liver injury, acquired immunodeficiency syndrome, Alzheimer disease, transplantation immune, immuno neurologic disfunction and mucosal tolerance, and consequently to provide new ideas on pharmacological study of AIIDs and therapy of inflammatory and immunological diseases.