| 化浊解毒活血通络法对脑缺血再灌注损伤小鼠行为学及海马神经细胞形态学的影响 |
| |
| 引用本文： | 赵见文,田军彪,李佃贵,张颜伟,杨丽静,刘学飞.化浊解毒活血通络法对脑缺血再灌注损伤小鼠行为学及海马神经细胞形态学的影响[J].中医杂志,2011(17):1492-1495. |
| |
| 作者姓名： | 赵见文 田军彪 李佃贵 张颜伟 杨丽静 刘学飞 |
| |
| 作者单位： | 河北医科大学中医院,河北省石家庄市中山东路,050011 |
| |
| 基金项目： | 国家中医药管理局重点研究室第一批建设项目，河北省中医药管理局2010年度中医药类科研计划课题 |
| |
| 摘 要： | 目的探讨化浊解毒活血通络法对脑缺血再灌注损伤的作用机制。方法将50只昆明小鼠随机分为假手术组、模型组、中药高剂量组、中药低剂量组、尼莫地平组,每组10只。采用线栓法制造小鼠右侧大脑中动脉脑缺血再灌注模型。手术造模成功后假手术组、模型组灌服生理盐水20ml/(kg.d),尼莫地平组灌服尼莫地平液19.6g/(kg.d),中药高剂量组、中药低剂量组分别给予化浊解毒活血通络中药19.6g/(kg.d)及9.8g/(kg.d)灌服。均每日1次,14天后进行行为学测试,并通过光镜观察小鼠海马CA1区的病理形态学改变。结果与模型组相比,中药高剂量组能提高脑缺血再灌注损伤小鼠的学习和记忆成绩,改善小鼠海马CA1区的神经细胞形态学表现,并且优于尼莫地平组和中药低剂量组(P<0.05)。结论化浊解毒活血通络法对脑缺血再灌注损伤小鼠的行为学能力及海马CA1区的神经细胞具有保护作用,这可能是该法对抗脑缺血再灌注损伤的机制之一。
|
| 关 键 词： | 化浊解毒活血通络法 脑缺血再灌注损伤 浊毒 行为学 海马CA1区 |
Effect of Huazhuo Jiedu Huoxue Tongluo Method on Behavioral and Morphological Changes of Nerve Cells in Hippocampal of Mice with Cerebral lschemia Reperfusion Injury |
| |
| ZHAO Jianwen,TIAN Junbiao,LI Diangui,ZHANG Yanwei,YANG Lijing,LIU Xuefei.Effect of Huazhuo Jiedu Huoxue Tongluo Method on Behavioral and Morphological Changes of Nerve Cells in Hippocampal of Mice with Cerebral lschemia Reperfusion Injury[J].Journal of Traditional Chinese Medicine,2011(17):1492-1495. |
| |
| Authors: | ZHAO Jianwen TIAN Junbiao LI Diangui ZHANG Yanwei YANG Lijing LIU Xuefei |
| |
| Institution: | ZHAO Jianwen,TIAN Junbiao,LI Diangui,ZHANG Yanwei,YANG Lijing,LIU Xuefei(TCM Hospital of Hebei Medical University,Shijiazhuang 050011) |
| |
| Abstract: | Objective To explore the mechanism of Huazhuo Jiedu Huoxue Tongluo method(method to dissolve turbidity,remove toxic substance,activate blood,and remove obstruction in meridian)on cerebral ischemia reperfusion injury(CIRI)model mice.Methods Fifty Kunming mice were randomized into sham-operated group,model group,Chinese medicine highdose group,Chinese medicine low-dose group,and Nimodipine group,with 10in each.Except the sham-operated group,the other 4groups were made CIRI models of right middle cerebral arte... |
| |
| Keywords: | Huazhuo Jiedu Huoxue Tongluo method(method to dissolve turbidity remove toxic substance activate blood and remove obstruction in meridian) cerebral ischemia reperfusion injury(CIRI) turbidity toxin behavior hippocampal CA1region |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
|
