Serum estrogens and androgens in women with endometrial carcinoma |
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| Authors: | B Pettersson R Bergstr?m E D Johansson |
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| Affiliation: | 1. Département de médecine générale, Faculté de Médecine, Université Picardie Jules Verne, 3 rue des Louvels, 80000 Amiens, France;2. Service de gynécologie et d''obstétrique, CHU Amiens Picardie, 1 Bd du Pr Christian Cabrol, 80054 Amiens, France;3. Faculté de Médecine, Université Picardie Jules Verne, 3 rue des Louvels, 80000 Amiens, France;1. Kelly Gynecologic Oncology Service, Department of Gynecology and Obstetrics, Johns Hopkins Medicine, Baltimore, MD, USA;2. Department of Gynecologic Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA;3. Department of Gynecologic Oncology and Reproductive Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA;4. Division of Gynecologic Oncology, Mayo Clinic, Rochester, MN, USA;5. Department of Obstetrics and Gynecology, Weill Cornell Medical College, New York, NY, USA;6. Moores Cancer Center, University of California, San Diego, La Jolla, CA, USA;1. Department of Obstetrics and Gynecology, McGill University, Montreal, Québec, Canada.;2. Department of Clinical Sciences and Community Health, Università degli Studi and Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, Italy. |
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| Abstract: | ![]()
Fifty-two postmenopausal women with newly diagnosed endometrial carcinoma and 58 postmenopausal age-matched controls were studied concerning serum levels of estrone, total estrone, estradiol, androstenedione, testosterone, dehydroepiandrosterone and its sulphate, sex steroid hormone binding globulin, follicle stimulating hormone, and luteinizing hormone. The patients had a higher mean serum level of estradiol (P = 0.006) and a lower level of follicle stimulating hormone (P = 0.001) than the controls and the significant differences remained after the number of years since the menopause and body index had been taken into account. As the serum levels of steroid hormone binding globulin tended to be lower among patients than among controls (P = 0.084), the difference in the biological effect of estradiol between the two groups was probably greater than the difference in serum concentrations would indicate. No significant difference in the ratio of estrone to androstenedione or in the mean serum level of androstenedione was found between patients and controls. These data support the role of estrogen in the etiology of endometrial carcinoma. |
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