| 免疫球蛋白A肾病病理形态学的初步研究(附150例肾活检光镜及电镜观察) |
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| 引用本文： | 张太和,陈惠平,赵惠玲.免疫球蛋白A肾病病理形态学的初步研究(附150例肾活检光镜及电镜观察)[J].解放军医学杂志,1988(5). |
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| 作者姓名： | 张太和 陈惠平 赵惠玲 |
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| 作者单位： | 南京军区南京总医院
(张太和，陈惠平)，南京军区南京总医院(赵惠玲) |
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| 摘 要： | 对150例IgA肾病的肾活检标本进行了光镜及透射电镜的形态学观察,其组织学改变由轻微病变至弥漫性系膜增殖,根据病变的严重程度作者将其分为6个亚型。系膜基质的增生为其突出的超微结构改变,常显示为局灶节段性、球性系膜细胞增殖和显著的系膜基质的增加。电子致密沉着多见于系膜基质及内皮细胞下,这些沉着物的多少与病变的严重程度未见有肯定的联系。
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| 关 键 词： | 免疫球蛋白A 肾病 |
A PRELIMINARY PATHOLOGICAL STUDY OF IgA NEPHROPATHY-LIGHT-AND ELECTRON MICROSCOPIC OBSERVATION |
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| Zhang Taihe,et al..A PRELIMINARY PATHOLOGICAL STUDY OF IgA NEPHROPATHY-LIGHT-AND ELECTRON MICROSCOPIC OBSERVATION[J].Medical Journal of Chinese People's Liberation Army,1988(5). |
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| Authors: | Zhang Taihe |
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| Institution: | Zhang Taihe,et al. General Hospital of Nanjing Command,PLA |
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| Abstract: | In this study, renal biopsy specimens from 150 cases of IgA nephropathy were studied with light-and electron microscopically. Histological lesions from minimal change to diffuse mesangial proliferation were observed. According to the degree of the renal lesions, the 150 cases were divided into 6 subtypes. Proliferation of mesangial matrix was found to be the striking ultrastructural alteration, which often appeared as focal segmental or global proliferation of mesangial cells, as well as marked increase in mesangial matrix. Electron-dense deposits were largely localized in mesangial matrix and in suben dothelial regions. However, no positive correlation could be seen between the number of the deposits and the degree of the lesions. |
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| Keywords: | immunoglobulin A Nephropathy |
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