结节性痒疹皮损表皮中血管活性肠肽的检测

目的　了解血管活性肠肽 (VIP)在结节性痒疹 (PN )发病中的作用。方法　采用免疫组化的方法检测 13例PN患者皮损中表皮VIP的含量 ,并与该 13例PN患者的非皮损区及 13例健康志愿者的正常皮肤进行了对照。结果　皮损中VIP水平明显高于正常皮肤及非皮损区 (P均 <0 .0 5 ) ,非皮损区与正常皮肤VIP水平比较差异无显著性 (P >0 .0 5 )。皮损区染色阳性主要分布在基底层和棘层的细胞膜和细胞质 ,正常皮肤和患者非皮损区则主要表达于表皮的基底层。结论　VIP水平增高在PN的发病中起重要作用。

Detection of Vasoactive Intestinal Peptide In Epidermis of Pruigo Nodularis Lesions

Objective To study the function of the VIP in pathogenesis of PN.Methods The samples of the lesions from 13 patients with PN,non lesions from the same patients and normal skin from 13 volunteers were detected with immunohistochemistry.Results Compared with the normal controls and non lesions, the mean level of VIP level in epidermis of lesions with PN was significanty higher( P <0.05),and there isn’t significant difference between former two group( P >0.05).Conclusion The higher level of VIP in the lesions of patients with PN might play an important role in the pathogenesis.