Neuroprotective effects of daidzein on focal cerebral ischemia injury in rats |
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| Authors: | Adem Bozkurt Aras Mustafa Guven Tar?k Akman Adile Ozkan Halil Murat Sen Ugur Duz Y?ld?ray Kalkan Coskun Silan Murat Cosar |
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| Affiliation: | 1.Department of Neurosurgery, Canakkale Onsekiz Mart University, Canakkale, Turkey;2.Department of Neurology, Canakkale Onsekiz Mart University, Canakkale, Turkey;3.Department of Medical Biochemistry, Ministry of Health, Administration of Public Health, Hakkari, Turkey;4.Deparment of Histology and Embryology, Recep Tayyip Erdoğan University, Faculty of Medicine, Rize, Turkey;5.Department of Pharmacology, Canakkale Onsekiz Mart University, Canakkale, Turkey |
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| Abstract: | ![]()
Daidzein, a plant extract, has antioxidant activity. It is hypothesized, in this study, that daidzein exhibits neuroprotective effects on cerebral ischemia. Rat models of middle cerebral artery occlusion were intraperitoneally administered daidzein. Biochemical and immunohistochemical tests showed that superoxide dismutase and nuclear respiratory factor 1 expression levels in the brain tissue decreased after ischemia and they increased obviously after daidzein administration; malondialdehyde level and apoptosis-related cysteine peptidase caspase-3 and caspase-9 immunoreactivity in the brain tissue increased after ischemia and they decreased obviously after daidzein administration. Hematoxylin-eosin staining and luxol fast blue staining results showed that intraperitoneal administration of daidzein markedly alleviated neuronal damage in the ischemic brain tissue. These findings suggest that daidzein exhibits neuroprotective effects on ischemic brain tissue by decreasing oxygen free radical production, which validates the aforementioned hypothesis. |
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| Keywords: | nerve regeneration brain ischemia stroke daidzein oxidative stress apoptosis superoxide dismutase malondialdehyde nuclear respiratory factor 1 neural regeneration |
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