经母婴传播丙型肝炎病毒婴儿10年转归的研究

目的：了解丙型肝炎病毒(HCV)母婴传播的远期预后。方法：应用前瞻性研究方法，对13例母婴传播感染HCV婴儿的转归进行了10年的随访。使用聚合酶链反应(PCR)检测HCVRNA，用第二代EIA试剂检测抗HCV。结果：临床型丙型肝炎1例，血清中抗-HCV和HCV RNA分别持续7年和8年；亚临床型丙型肝炎3例，2例血清中抗-HCV于l2月龄阴转，1例于24月龄阴转，2例HCV RNA于24月龄阴转，1例于60月龄阴转；隐性感染9例，血清中抗-HCV和HCV RNA均在12月龄内阴转。随访8～10年未发现抗-HCV和HCV RNA再次转阳者。结论：提示HCV母婴传播形成HCV慢性携带和丙型肝炎慢性化的机率较低，转归较好，对婴儿生长发育影响不大。

Ten years outcome observation of infants with hepatitis C virus mother to infant transmission

Objective To study the outcome of hepatitis C virus (HCV) vertical transmitted infants. Methods Thirteen HCV vertical infected infants were followed up for 10 years. HCV antibody and HCV RNA in the blood samples from them were tested using second generation HCV antibody EIA kits and RT-PCR, respectively. Results Among the 13 infants, one developed clinical hepatitis C, and serum HCV antibody and HCV RNA could be detected for 7 and 8 years, respectively. Three were subclinical hepatitis C, serum HCV antibody continued to be positive for 12 months (2 infants) and 24 months (1 infant), respectively, and serum HCV RNA turned to be negative at the 24th month (2 infants) and the 60th month (1 infant), respectively. Nine were HCV insidious infection, whose serum HCV antibody and HCV RNA turned to be negative in 12 months. During the eight to ten years, there was no infants with anti-HCV or HCV RNA positive again. Conclusions It is rarely happened that vertical transmitted HCV induce chronic HCV carrying state and chronic viral hepatitis, and most of the infected infants have good outcome.