地方性克汀病家庭聚集的讨论

本文收集泰安地区下港乡和肥城县柳林村两个病区145例克汀病患者的家庭分布资料,采用 G 统计量齐性检验和二项分布拟合检验方法,作家庭聚集性研究,同时做了9例地克病人的染色体检查,发现两病区均有家庭聚集性存在,并与家庭中病人多少有关。提出调查单位较小,结果不一致时应以 G 统计量结果为准。地克病家庭聚集性的存在,提示有与遗传因素或血缘有关的可能,统计分析结果并不证实一定有遗传关系,本文地克病人染色体检查均属正常,不能证实有遗传因素。但也不能排除遗传的影响,作染色体检查仅能初步排除染色体遗传病。

Discussion of familial clustering of endemic cretinism

The author made a research of familial clustering from the family distributiondata of 145 patients with endemic cretinism in two endemic areas (Xia gang andLiu lin).using G statistic,homogeneity test and binomial distribution fit test.Atthe same time,chromosome examination was also done among 9 of the 145 Patients.The familial clustering existed in both of the two areas,and related to the numberof patients in family,As regards the survey unit being small,the G statistic shouldbe the standard.The existing familial clustering of endemic cretinism suggests thepossibility of genetic factor or kinship,but does not demonstrate that diseasemust have relationship with genetic factor.Although all of the chromosome exami-nations done in this survey are normal,still genetic factor can neither be demonst-rated nor excluded.The examination of chromosome can only primarily excludechromosomal genetic disease.