| 关节康片的抗炎镇痛作用及毒性观察 |
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| 引用本文： | 王丽新,邹衍衍,樊粤光.关节康片的抗炎镇痛作用及毒性观察[J].中药新药与临床药理,2005,16(6):417-420. |
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| 作者姓名： | 王丽新 邹衍衍 樊粤光 |
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| 作者单位： | 广州中医药大学第一附属医院,广州,510405 |
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| 摘 要： | 目的观察关节康片抗炎镇痛药理作用及其动物毒性反应情况.方法采用大鼠足跖肿胀试验、大鼠毛细血管通透性实验、小鼠扭体法镇痛试验和小鼠急性毒性试验.结果关节康片能明显减少醋酸所致小鼠扭体反应次数(P＜0.01),减轻甲醛所致大鼠足跖肿胀(P＜0.01),但对组胺所致大鼠毛细血管通透性增高无降低作用(P＞0.05);小鼠口服半数致死量LD50为1.74 g/kg.结论关节康片有较好的镇痛作用及部分抗炎作用,但也具有一定毒性.
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| 关 键 词： | 关节康片 骨关节炎 抗炎镇痛 中药毒性 |
| 文章编号： | 1003-9783（2005）06-0417-04 |
| 收稿时间： | 2005-07-01 |
| 修稿时间： | 2005年7月1日 |
Anti - inflammatory and Analgesic Actions of Guanjiekang Tablet and Its Toxicity |
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| WANG Lixin,ZOU Yanyan,FAN Yueguang.Anti - inflammatory and Analgesic Actions of Guanjiekang Tablet and Its Toxicity[J].Traditional Chinese Drug Research & Clinical Pharmacology,2005,16(6):417-420. |
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| Authors: | WANG Lixin ZOU Yanyan FAN Yueguang |
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| Institution: | First Affiliated Hospital of Guangzhou University of TCM , Guangzhou 510405 |
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| Abstract: | Objective To study the anti-inflammation and analgesic action s of Guanjiekang Tablet and to observe its toxicity.Methods Rat pedal swelling experiment,rat capillary permeability experiment,mouse acetic-acid-induced twisting experiment and mouse acute toxicity experiment were carried out in this study.Results Guanjiekang Tablet could obviously reduce the twisting times in mice(P <0.01) and relieve rat pedal swelling induced by formaldehyde(P<0.01),but had no effect on reducing the rat capillary permeability induced by histamine(P>0.05).The LD50 of oral dose in mice is 1.74(g/kg).Conclusi ons Guanjiekang Tablet has good anti-inflammation and analgesic actions,but also has some toxicity. |
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| Keywords: | Guanjiekang Tablet Osteoarthritis Anti-inflammation Analgesic Toxicity |
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