In vivo-induced genes in Pseudomonas aeruginosa |
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| Authors: | Handfield M Lehoux D E Sanschagrin F Mahan M J Woods D E Levesque R C |
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| Affiliation: | Microbiologie Moléculaire et Génie des Protéines, Pavillon Charles-Eugène Marchand, Faculté de Médecine, Université Laval, Sainte-Foy, Québec, Canada G1K 7P4. |
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| Abstract: | In vivo expression technology was used for testing Pseudomonas aeruginosa in the rat lung model of chronic infection and in a mouse model of systemic infection. Three of the eight ivi proteins found showed sequence identity to known virulence factors involved in iron acquisition via an open reading frame (called pvdI) implicated in pyoverdine biosynthesis, membrane biogenesis (FtsY), and adhesion (Hag2). |
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