| C-erbB-2、PCNA、ER、PR在乳腺癌中的表达及临床意义 |
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| 引用本文： | 马莉琼,杨治花. C-erbB-2、PCNA、ER、PR在乳腺癌中的表达及临床意义[J]. 宁夏医学杂志, 2009, 31(2): 104-105 |
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| 作者姓名： | 马莉琼 杨治花 |
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| 作者单位： | 宁夏医科大学附属医院,宁夏,银川,750004;宁夏医科大学附属医院,宁夏,银川,750004 |
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| 摘 要： | 目的探讨分析乳腺癌组织中C—erbB-2、增殖细胞核抗原（PCNA）及雌、孕激素受体（ER、PR）的表达及其意义。方法采用免疫组化法检测269例乳腺癌组织中C—erbB-2、PCNA、ER、PR的表达情况。结果乳腺癌组织中C—erbB-2、PCNA、ER、PR的阳性表达率分别为69．52％、78．81％、51．67％和59．48％。C—erbB-2表达与乳腺癌患者腋淋巴结转移及肿瘤的浸润性相关（P〈0．01）;PCNA表达仅与腋淋巴结转移相关（P〈0．01）,而与肿瘤的浸润性无关（P〉0．05）;ER、PR表达呈正相关（r=0．522,P=0．000）,C—erbB-2、PCNA表达呈正相关（r=0．182,P=0．003）。结论联合检测乳腺癌组织中C—erbB-2、PCNA、ER、PR的表达对于乳腺癌的治疗具有指导意义,也是判断预后的重要指标。
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| 关 键 词： | 乳腺癌 C-erbB-2 PCNA ER PR |
Expression and clinical significance of C-erbB-2,PCNA,ER and PR in breast Cancer |
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| MA Li-qiong,YANG Zhi-hua. Expression and clinical significance of C-erbB-2,PCNA,ER and PR in breast Cancer[J]. Ningxia Medical Journal, 2009, 31(2): 104-105 |
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| Authors: | MA Li-qiong YANG Zhi-hua |
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| Affiliation: | The Affiliated Hospital of Ningxia Medical University;Yinchuan 750004;China |
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| Abstract: | Objective To investigate the expression and clinical significance of C-erbB-2, PCNA, ER and PR in breast cancer.Methods Expression of C-erbB-2, PCNA, ER and PR were detected by using immunohistochemical method in 269 breast cancer tissues.Results Positive rates of C-erbB-2, PCNA, ER and PR were found to be 69.52%, 78.81%, 51.67% and 59.48%, respectively. The expression of C-erbB-2 was correlated with lymph node metastasis and tumorous invasion (P<0.05). The expression of PCNA was only correlated with lymph ... |
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| Keywords: | C-erbB-2 PCNA ER PR |
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