Effect of age on mechanical properties of the collagen phase in different orientations of human cortical bone |
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| Affiliation: | 1. Department of Orthopaedics, Peking University Third Hospital, China;2. Mechanical Engineering, University of Texas at San Antonio, USA;3. Department of Health and Kinesiology, University of Texas at Tyler, USA;1. Department of Medicine, Division of Endocrinology, Metabolism, and Diabetes, University of Colorado Anschutz Medical Campus, Aurora, CO, United States of America;2. Tufts University School of Medicine, Maine Medical Center Research Institute Scarborough, ME, United States of America |
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| Abstract: | ![]()
The collagen phase plays an important role in mechanical behaviors of cortical bone. However, aging effects on the mechanical behavior of the collagen phase is still poorly understood. In this study, micro-tensile tests were performed on demineralized human cortical bone samples from young, middle-aged, and elderly donors and aging effects on the mechanical properties of the collagen phase in different orientations (i.e. longitudinal and transverse directions of bone) were examined. The results of this study indicated that the elastic modulus and ultimate strength of the demineralized bone specimens decreased with aging in both the longitudinal and transverse orientations. However, the failure strain exhibited no significant changes in both orientations regardless of aging. These results suggest that the stiffness and strength of the collagen phase in bone are deteriorated with aging in both longitudinal and transverse directions. However, the aging effect is not reflected in the failure strain of the collagen phase in both longitudinal and transverse orientations, implying that the maximum sustainable deformation of the collagen phase is independent of aging and orientation. |
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