|
|||||
|
|
| 人视网膜下膜中ICAM-1及MMP-2的免疫组织化学研究 | |
| 引用本文： | 李林,李斌,杨安怀,赵婷秀,邢怡桥. 人视网膜下膜中ICAM-1及MMP-2的免疫组织化学研究[J]. 眼科新进展, 2005, 25(6): 519-521 |
| 作者姓名： | 李林 李斌 杨安怀 赵婷秀 邢怡桥 |
| 作者单位： | 1. 511400,广东省广州市番禺区人民医院眼科 2. 430060,湖北省武汉市,武汉大学人民医院眼科 3. 430061,湖北省武汉市,湖北中医学院病理教研室 |
| 摘 要： | 目的观察增生性玻璃体视网膜病变的视网膜下膜中粘附分子（intercellular adhesion molecules-1，ICAM-1）及基质金属蛋白酶（matrix metculoproteinase-2，MMP-2）的表达。方法用免疫组织化学法对15例复杂视网膜脱离行玻璃体切割术时剥离的视网膜下膜进行观察。结果ICAM-1和MMP-2分别在10例和8例视网膜下膜中表达，二者同时在7例视网膜下膜中表达。结论视网膜下膜中有ICAM-1和MMP-2的表达，提示二者在增生性玻璃体视网膜病变的发生发展中有一定作用。 |
| 关 键 词： | 视网膜下膜 增生 粘附分子 基质金属蛋白酶 免疫组织化学 |
| 文章编号： | 1003-5141(2005)06-0519-03 |
| 收稿时间： | 2004-09-01 |
| 修稿时间： | 2005-01-11 |
Immunohistochemical study of adhesion molecules and matrix metalloproteinases in human subretinal membranes |
|
| LI Lin,LI Bin,YANG An-Huai,ZHAO Ting-Xiu,XING Yi-Qiao. Immunohistochemical study of adhesion molecules and matrix metalloproteinases in human subretinal membranes[J]. Recent Advances in Ophthalmology, 2005, 25(6): 519-521 | |
| Authors: | LI Lin LI Bin YANG An-Huai ZHAO Ting-Xiu XING Yi-Qiao |
| Abstract: | Objective To investigate the expression of intercellular adhesion molecules-1(ICAM-1) and matrix metalloproteinase-2(MMP-2)in subretinal membranes of patients with proliferative vitreoretinopathy (PVR).Methods Fifteen subretinal vitrectomy for retinal detachment complicated with PVR were performed and the abradant subretinal membranes were observed by immunohistochemistry.Results Expressions of ICAM-1 and MMP-2 were observed in 10 and 8 membranes respectively. Expression of both in 7 subretinal membrane.Conclusion ICAM-1 and MMP-2 could be expressed in subretinal membranes of eyes with PVR.These results indicated that adhesion molecules and matrix metalloproteinase might be involved in the development of PVR. |
| Keywords: | subretinal membranes hyperpl-asia -adhesionmolecules matrix mctalloproteinases lmmunohistochemist ry |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |