| 磁性纳米粒阿霉素微球制备的初探 |
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| 引用本文： | 林本兰,沈晓冬,崔升,施瑞华,凌亭生.磁性纳米粒阿霉素微球制备的初探[J].中国医院药学杂志,2005,25(5):424-426. |
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| 作者姓名： | 林本兰 沈晓冬 崔升 施瑞华 凌亭生 |
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| 作者单位： | 1. 南京工业大学材料科学与工程学院,江苏,南京,210009
2. 南京医科大学第一附属医院,江苏,南京,210029 |
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| 摘 要： | 目的:制备靶向抗癌药物即磁性纳米粒阿霉素白蛋白微球.方法:以阿霉素(ADR)、人血清白蛋白(HSA)和纳米Fe3O4为材料,采用乳化高温固化法制备出磁性纳米粒阿霉素白蛋白微球,并利用Hrtem对其包裹结合性能进行了观察,同时采用HPLC法对其载药量进行测试.结果:有效载药量为2.35%、表观载药量为3.55%.结论:采用乳化高温固化法能制备出磁性纳米粒阿霉素白蛋白微球.
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| 关 键 词： | 阿霉素 靶向抗癌药物 制备 表现载药量 有效载药量 |
| 文章编号： | 1001-5213(2005)05-0424-03 |
| 收稿时间： | 2004-09-30 |
| 修稿时间： | 2004年9月30日 |
Synthesis and characterization of magnetic nanoparticle to control releasing of adriamycin |
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| LIN Ben-lan,Shen Xiao-dong,Cui Sheng,SHI Rui-hua,LING Ting-sheng.Synthesis and characterization of magnetic nanoparticle to control releasing of adriamycin[J].Chinese Journal of Hospital Pharmacy,2005,25(5):424-426. |
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| Authors: | LIN Ben-lan Shen Xiao-dong Cui Sheng SHI Rui-hua LING Ting-sheng |
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| Institution: | 1. College of Material Science and Technology,Jiangsu Nanjing 210009,China ;2. The First Affiliated Hospital of Nanjlng Medical University,Jiangsu Nanjing 21002% China |
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| Abstract: | OBJECTIVE To prepare adriamycin-loaded magnetic albumin micro,spheres. METHODS To prepare adriamycin-loaded alhumin mierospheres with magnetic Fe3O4 nanoparticles by emulsion heating solidification method with adriamycin, HAS and Fe3 04 nanoparticle. Gained parcel degree by TEM and the adriamycin content by HPLC. RESULTS The efficiency loading amount of adriamyein-loaded alhumin mierospheres with magnetic nanoparticles was 2. 35% and the apparent loading amount was 3.55%. CONCLUSION Emulsion heating solidification method could be used for preparation of adriamycin loaded albumin microspheres |
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| Keywords: | adriamycin target-orientation anticancer drug synthesis apparent drug loading effective drug loading |
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