青少年体重指数与血清瘦素等生化指标之间的关系

目的研究青少年肥胖程度与血清瘦素、胰岛素、血糖及血脂等的相关性,为成年期疾病的早期预防提供相关依据。方法随机选取83名中学生,其中肥胖学生47名,正常学生36名。测定血清瘦素、胰岛素、血糖及血脂等指标,计算胰岛素抵抗指数（HOMA-IR）。结果除血糖外,血清各项检测指标肥胖组均高于正常组（P值均〈0.05）;83名中学生BMI和血清瘦素及其他各项指标均呈显著正相关（P值均〈0.05）。女生只有三酰甘油、胰岛素和胰岛素抵抗指数与瘦素水平显著正相关。结论BMI对血清瘦素水平影响最明显,对糖、脂代谢的影响相对较小;肥胖组存在明显的高瘦素血症（瘦素抵抗）、高胰岛素血症、胰岛素抵抗（IR）和轻微的脂代谢异常。

Relationship Between BMI and Serum Leptin and Other Biochemical Indices in Adolescents

Objective To investigate the relationship between BMI and serum leptin,insulin,serum glucose and lipid in adolescence,and to provide evidence for the early prevention of adulthood diseases.Methods Eighty-three students were chosen randomly,47 were obese and the other 36 were normal.Their fasting serum levels of leptin insulin,glucose,total cholesterol(TC),triglyceride(TG)and low density lipoprotein(LDL)were analyzed,and homeostasis model assessment of insulin resistance(HOMA-IR)were calculated.Results The indices in obese adolescents were higher than the normal except glucose(P<0.05).BMI and serum leptin were positively correlated with serum indices but glucose(P<0.05).In female obese students,only TG,insulin and HOMA-IR were positively correlated with serum leptin.Conclusion BMI influences serum leptin significantly and slightly influences glucose and lipid metabolism.High prevalence of hyperleptinemia,hyperinsulinism,insulin resistant(IR)and slightly abnormity in lipid metabolism.