| 肾细胞癌中血管内皮生长因子的表达 |
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| 引用本文： | 张前,吴宏飞,钱立新. 肾细胞癌中血管内皮生长因子的表达[J]. 现代泌尿外科杂志, 2003, 8(4): 219-221 |
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| 作者姓名： | 张前 吴宏飞 钱立新 |
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| 作者单位： | 1. 南京医科大学第三附属医院泌尿外科,江苏,仪征,211900
2. 南京医科大学第一附属医院泌尿外科,江苏,南京,210029 |
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| 摘 要： | 目的 探讨肾癌组织中血管内皮生长因子的表达及其与肾癌生物学行为的关系。方法 应用单克隆鼠抗-VEGF抗体通过免疫组化SP法研究肾癌中血管内皮生长因子的表达。结果 60例肾癌组织中35例(58.3％)血管内皮生长因子阳性。血表达与组织学分级(P<0.05)和TNM分期(P<0.05)均明显相关。 结论 血管内皮生长因子表达对肾癌生物学行为有重要影响,设法抑制血管内皮生长因子有望成为肾癌治疗的另一有效方法。
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| 关 键 词： | 肾细胞癌 血管内皮生长因子 生物学行为 预后 免疫组织化学 |
| 文章编号： | 1009-8291(2003)04-0219-02 |
| 修稿时间： | 2002-10-14 |
Eypression of vascular endothelial growth factor in renal cell carcinoma |
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| ZHANG Qian WU Hong-fei QIAN Li-xin. Eypression of vascular endothelial growth factor in renal cell carcinoma[J]. Journal of MOdern Urology, 2003, 8(4): 219-221 |
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| Authors: | ZHANG Qian WU Hong-fei QIAN Li-xin |
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| Abstract: | AIM To investigate the expression of vascular endothelial growth factor (VEGF) in renal cell carcinoma (RCC)and the relationship between VEGF and biological behavior of RCC. METHODS Immunohistochemical analysis of VEGF was performed by applying the streptavidin peroxidase(SP) conjugated method. RESULTS Thirty-five tumors (58.5%) were classified as VEGF positive. A significant correlation was found between VEGF expression and both the nuclear grade (P<0.05) and the TNM stage (P<0.05). CONCLUSION Expression of VEGF has an important influence on the biological behavior of RCC. Its inhibition might be further used in the treatment of RCC. |
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| Keywords: | renal cell carcinoma immunohistochemistry vascular endothelial growth factor |
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