我国锡矿尘诱癌实验研究

采用雄性3月龄Wistar 大鼠(体重180～220g)350只,分7组:(1)香花岭Ⅰ号矿尘组(含砷32.0%),6mg/次;(2)香花岭Ⅱ号矿尘(含砷2.2%),6mg/次;(3)香花岭Ⅲ号矿尘(含砷0.54%),6mg/次;(4)广西大厂锡矿选厂粉尘(含砷1.9%),6mg/次;(5)生理盐水对照组,0.2ml/次;(6)自然对照组;(7)3-MCA 阳性对照组,10mg,只注一次。每组50只大鼠。粉尘粒子直径在10μm 以下者占90%。大鼠乙醚麻醉,气管内灌0.2ml 生理盐水粉尘混悬液,每周一次,共10次。实验期限为二年。病理常规方法。每组诱发肺癌结果分别为:(1)2/38(5.0%);(2)2/48(4.0%);(3)2/46(4.0%);(4)0/42;(5)0/44;(6)4/31(12.9%)。结果表明各组肺癌诱发率与矿尘中的含砷量并无剂量-反应关系。

The Study of Lung Cancer Induced in Rats by Tin Ore Dust

350 adult male Wister rats(body weight 180～200g)were used in thestudy.The rats were divided into seven groups:physiological saline as con-trol group,0.2ml/once;natural control group;3-MCA as poitive controlgroup,10mg,only once,and four other experimental groups.There werefifty rats in each group.The diameter of ore dust less than 10μm account-ed for more than 90%.The rats were anesthesized by ethyl ether,and then0.2ml physiological saline mixed with ore dust were instilled intratrache-ally once a week,for ten times totally.The stretch of experiment has beenlasted for two years.Pathological routine examination was applied in thestudy.The result of lung cancer induced in each group were recorded res-pectively as follows:(1)2/38(5.0%);(2)2/48(4.0%);(3)2/46(4.0%);(4)0/42;(5)0/44;(6)4/32(12.9%).The result showsthat there is no dose-response relation between the incidence of lung can-cer of each group and of the content of arsenic in ore dust.