系统性红斑狼疮患者左心功能的应变和应变率研究

目的 探讨应变和应变率显像评价系统性红斑狼疮(SLE)患者左心功能的临床应用价值.方法 60例正常人与62例SLE患者均接受常规超声及组织多普勒检测,获取二尖瓣血流E/A值、左室短轴缩短率(LVFS)、左室射血分数(LVEF)及左室心肌的收缩期及舒张期峰值应变和应变率.结果 ①SLE组和正常对照组E/A值、LVFS及LVEF无明显差异(P＞0.05);SLE组心肌的收缩期应变、应变率峰值低于正常对照组,但差异无统计学意义(P＞0.05).②SLE组舒张期应变率峰值低于正常对照组且差异有统计学意义(P＜0.01).③SLE组抗心肌抗体(AHA)阳性者心肌舒张期应变率峰值低于AHA阴性者(P＜0.05).结论 应变及应变率与AHA结合可以敏感检测SLE患者左心功能的早期损害.

Study of strain and strain rate imaging in systemic lupus erythematosus

Objective To investigate the diagnosis value of the tissue strain imaging in myocardial dysfunction in systemic lupus erythematosus (SLE). Methods Sixty-two patients and sixty controls underwent conventional and tissue Doppler echocardiography. Peak strain and strain rate value during systolic and diastolic phases as well as E/A, left ventricular fraction shortening (LVFS), left ventricular ejection fraction(LVEF) were measured in both SLE and the control groups. Results ①E/A,LVFS and LVEF did not differ between SLE patients and controls( P ＞0.05). The systolic peak strain and strain rate of SLE patients were lower than those of controls but without significant differences( P ＞0.05). ②The diastolic peak strain and strain rate of SLE patients were significantly lower than those of controls (P ＜0.01). ③ The diastolic peak strain and strain rate of antiheart antibody (AHA) positive patients were significantly lower than those of negative ones( P ＜0.05). Conclusions Strain and strain rate combining with AHA can sensitively detect myocardial dysfunction of SLE.