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糖尿病心血管自主神经病变检查方法的研究进展
引用本文:毛跟红,陈贵安. 糖尿病心血管自主神经病变检查方法的研究进展[J]. 国际内分泌代谢杂志, 2007, 29(1): 50-53. DOI: 10.3760/cma.j.issn.1673-4157.2009.s1.017
作者姓名:毛跟红  陈贵安
作者单位:复旦大学内分泌糖尿病研究所;复旦大学附属华山医院内分泌科,上海 200032
摘    要:
目前无创检测糖尿病心血管自主神经病变(DCAN)的方法有标准心血管反射试验、心率变异性(HHV)和压力反射敏感性(BRS)分析等,可用于糖尿病患者心血管自主神经功能的评估以及分析DCAN和血糖控制、肥胖、心源性猝死、颈动脉硬化、胰岛素抵抗及运动治疗等的关系。另外,影像学方法如核素显像检测也可应用于DCAN,并可提供糖尿病患者心脏失去自主神经支配的直接证据。

关 键 词:糖尿病 自主神经病变 心率变异性 压力反射敏感性 心血管疾病
修稿时间:2006-04-12

Stem-cell therapy for diabetes mellitus
MAO Gen-hong,CHEN Gui-an. Stem-cell therapy for diabetes mellitus[J]. International JOurnal of Endocrinology and Metabolism, 2007, 29(1): 50-53. DOI: 10.3760/cma.j.issn.1673-4157.2009.s1.017
Authors:MAO Gen-hong  CHEN Gui-an
Affiliation:Institute of Endocnology and Diabetology at Fudan University; Department of Endocrinology, Huashan Hospital, Fudan University, Shanghai 200032, China
Abstract:
Nowadays there are some non-invasive methods of testing diabetic cardiovascular autonomic neuropathy(DCAN),including standard cardiovascular reflex tests,heart rate variability(HRV) analysis and baroreflex sensitivity(BRS) analysis.The three methods have been used to estimate cardiovascular autonomic function in people with diabetes and to evaluate the relationship between DCAN and glucose control,obesity,cardiac sudden death,carotid atherosclerosis,insulin resistance,exercise therapy,etc.In addition,scintiscanning,including SPECT(single photon emission computed tomography) with [()(123)I]MIBG(()(123)I-metaiodobenzylguanidine) and PET(positron emission tomography) with [()(11)C]HED(()(11)C-hydroxyephedrine),can measure cardiovascular autonomic function invasively because it can supply the direct evidence of cardiac sympathetic dysinnervation in people with diabetes.
Keywords:Diabetes Mellitus   Autonomic neuropathy   Heart rate variability   Baroreflex sensitivity   Cardiovascular disease
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