Association of phosphodiesterase 4D gene G0 haplotype and ischaemic stroke in a Greek population |
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| Authors: | L. Fidani J. Clarimon A. Goulas A. I. Hatzitolios W. Evans E. Tsirogianni J. Hardy A. Kotsis |
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| Affiliation: | Department of General Biology, School of Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece;;Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA;;Department of Experimental Pharmacology, School of Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece;;First Propedeutic Department of Internal Medicine, AHEPA Hospital, School of Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece;;and Reta Lila Weston Institute of Neurology, Queen Square, London, UK |
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| Abstract: | ![]()
We have examined the association of phosphodiesterase 4D ( PDE4D ) single nucleotide polymorphism (SNP45) and microsatellite marker AC008818-1 with ischaemic stroke, in an independent cohort of Greek patients and control individuals with no clinical manifestations of vascular disease. Significantly different distributions were observed with respect to the AC008818-1 alleles, with allele 148 associating with an increased risk of stroke incidence, and allele 144 with a protective effect. In addition, the haplotype defined by allele 148 and G allele of SNP45 was found to be significantly increased in patients even though no statistically significant differences emerged with respect to SNP45 alone. The previously established association of a PDE4D gene haplotype with ischaemic stroke in a population from Iceland was independently confirmed in our Greek population, suggesting that PDE4D may be involved in the aetiology and pathogenesis of stroke. |
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| Keywords: | genetics gene polymorphism ischaemic stroke phosphodiesterase 4D |
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