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Efficacy and safety of oral panobinostat plus subcutaneous bortezomib and oral dexamethasone in patients with relapsed or relapsed and refractory multiple myeloma (PANORAMA 3): an open-label,randomised, phase 2 study
Authors:Jacob P Laubach  Fredrik Schjesvold  Mário Mariz  Meletios A Dimopoulos  Ewa Lech-Maranda  Ivan Spicka  Vania T M Hungria  Tatiana Shelekhova  Andre Abdo  Lutz Jacobasch  Chantana Polprasert  Roman Hájek  Árpád Illés  Tomasz Wróbel  Anna Sureda  Meral Beksac  Iara Z Gonçalves  Joan Bladé  Paul G Richardson
Affiliation:1. Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA;2. Oslo Myeloma Center, Oslo University Hospital, Oslo, Norway;3. KG Jebsen Center for B Cell Malignancies, University of Oslo, Oslo, Norway;4. Portuguese Institute of Oncology, Porto, Portugal;5. Department of Clinical Therapeutics, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece;6. Institute of Hematology and Transfusion Medicine, Warsaw, Poland;7. First Faculty of Medicine, Charles University and General Hospital in Prague, Prague, Czech Republic;8. São Germano Clinic, São Paulo, Brazil;9. Saratov State Medical University, Saratov, Russia;10. University of São Paulo Faculty of Medicine Hospital, São Paulo, Brazil;11. Group practice Freiberg-Richter, Jacobasch, Illmer, Wolf, Dresden, Germany;12. Department of Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand;13. Department of Hematooncology, University Hospital of Ostrava and Faculty of Medicine, Ostrava, Czech Republic;14. Department of Hematology, University of Debrecen, Faculty of Medicine, Debrecen, Hungary;15. Wroc?aw Medical University, Wroc?aw, Poland;p. Hematology Department, Institut Català d''Oncologia-Hospitalet, IDIBELL, Universitat de Barcelona, Barcelona, Spain;q. Ankara University, Ankara, Turkey;r. Fundacao Pio XII Barretos Cancer Hospital, Barretos, Brazil;s. Department of Hematology, IDIBAPS, Hospital Clinic, Barcelona, Spain;t. Mayo Clinic, Rochester, MN, USA;u. Icahn School of Medicine at Mount Sinai, New York, NY, USA;v. Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA, USA;w. Alfred Hospital-Monash University, Melbourne, VIC, Australia;x. Bichat-Claude Bernard Hospital (Paris Nord Val de Seine University Hospitals), Paris, France;y. University Hospital Hotel-Dieu, Nantes, France;z. Clinica Universidad de Navarra, Centro de Investigación Médica Aplicada, Instituto de Investigaciones Sanitarias de Navarra, Centro de Investigación Biomédica en Red de Cáncer, Pamplona, Spain
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