Labeling and tracking cells with gold nanoparticles |
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| Authors: | Ramya Chandrasekaran Thiagarajan Madheswaran Nagendran Tharmalingam Rajendran JC Bose Hansoo Park Don-Hyung Ha |
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| Affiliation: | 1. Department of Chemical Engineering, Monash University, Clayton, VIC, Australia;2. Department of Pharmaceutical Technology, School of Pharmacy, International Medical University, No. 126 Jalan Jalil Perkasa 19, Bukit Jalil, 57000 Kuala Lumpur, Malaysia;3. Infectious Diseases Division, Warren Alpert Medical School of Brown University, Rhode Island Hospital, Providence, RI 02903, USA;4. School of Integrative Engineering, Chung-Ang University, Seoul, Republic of Korea;5. Masonic Medical Research Institute, Utica, NY, USA |
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| Abstract: | ![]()
Gold nanoparticles (AuNPs) have garnered much attention as contrast agents for computerized tomography (CT) because of their facile synthesis and surface functionalization, in addition to their significant X-ray attenuation and minimal cytotoxicity. Cell labeling using AuNPs and tracking of the labeled cells using CT has become a time-efficient and cost-effective method. Actively targeted AuNPs can enhance CT contrast and sensitivity, and further reduce the radiation dosage needed during CT imaging. In this review, we summarize the state-of-the-art use of AuNPs in CT for cell tracking, including the precautionary steps necessary for their use and the difficulty in translating the process into clinical use. |
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