辅助性T细胞17与白细胞介素17在口腔黏膜疾病中的研究进展

辅助性T细胞17(T helper cells 17,Th17)细胞是一种新的CD4+T辅助细胞,其通过分泌特有的白细胞介素17(interleukin 17,IL-17)参与机体免疫及炎性反应.在口腔黏膜疾病中,口腔扁平苔藓(oral lichen pla-nus,OLP)、复发性阿弗他溃疡(recurrent ap...

Research progress on the role of T helper cells 17 and interleukin 17 in oral mucosal diseases

T helper 17(Th17)cells are a new type of CD4+T helper cell.They participate in the immune and inflam?matory response by secreting specific interleukin?17(IL?17).In oral mucosal diseases,oral lichen planus(OLP),recur?rent aphthous ulcer(RAU)and Behcet′s disease(BD)are associated with Th17 cells and IL?17.There were 17 kinds of proteins in the saliva of patients with OLP that could upregulate the expression of Th17 cells and induce the secretion of IL?17.IL?17 can stimulate epithelial cells,endothelial cells and fibroblasts to produce a variety of cytokines,such as IL?6,IL?8,granulocyte macrophage colony?stimulating factor and cell adhesion molecule?1,leading to the production and aggravation of inflammation.Th17/Tc17 cell?targeted therapy can significantly improve the clinical symptoms of OLP patients′mucosa and skin.IL?17 can stimulate oral keratinocytes through the IL?17RA or IL?17RE receptor and produce proinflammatory effects in RAU.Th17 cells in the peripheral blood of BD patients are significantly increased,while Treg cells are significantly decreased.