| 氟尿嘧啶炭纳米粒新型制剂的淋巴靶向性研究 |
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| 引用本文： | 邹志强,冀强,曹俊涵,赵书文,张丹. 氟尿嘧啶炭纳米粒新型制剂的淋巴靶向性研究[J]. 中国普外基础与临床杂志, 2011, 18(10): 1060-1062 |
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| 作者姓名： | 邹志强 冀强 曹俊涵 赵书文 张丹 |
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| 作者单位： | 1. 成都大学附属医院普通外科,四川成都,610081
2. 四川大学华西药学院,四川成都,610041 |
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| 摘 要： | 目的对氟尿嘧啶(5-FU)炭纳米粒新型制剂在大鼠体内的淋巴靶向性进行研究。方法采用反相高效液相色谱法测定大鼠经腹腔注射5-FU炭纳米粒新剂型与5-FU普通剂型(20mg/kg体重)后大鼠体内淋巴组织的药物浓度。结果腹腔注射5-FU炭纳米粒新剂型组中淋巴组织中药物浓度高于5-FU普通剂型组,炭纳米粒可以吸附5-FU并被淋巴组织吞噬,体现出一定的淋巴靶向性,5-FU炭纳米粒新剂型组中的5-FU在淋巴组织中持续时间较长。结论 5-FU炭纳米粒注射液能显著改善淋巴靶器官局部药物浓度,具有较好的淋巴靶向性。
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| 关 键 词： | 氟尿嘧啶 炭纳米粒 淋巴靶向性 |
Study on Lymphatic Targeting in Rats of New Dosage Form of 5-Fluorouracil Carbon Nanoparticles |
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| ZOU Zhi-qiang,JI Qiang,CAO Jun-han,ZHAO Shu-wen,ZHANG Dan. Study on Lymphatic Targeting in Rats of New Dosage Form of 5-Fluorouracil Carbon Nanoparticles[J]. Chinese Journal of Bases and Clinics In General Surgery, 2011, 18(10): 1060-1062 |
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| Authors: | ZOU Zhi-qiang JI Qiang CAO Jun-han ZHAO Shu-wen ZHANG Dan |
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| Affiliation: | ZOU Zhi-qiang1,JI Qiang1,CAO Jun-han2,ZHAO Shu-wen2,ZHANG Dan2.1.Department of General Surgery,Affiliated Hospital,Chengdu University,Chengdu 610081,Sichuan Province,China,2.West China School of Pharmacy,Sichuan University,Chengdu 610041 |
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| Abstract: | Objective To investigate the lymphatic targeting of 5-fluorouracil(5-FU) carbon nanoparticles in rats. Methods 5-FU concentration in lymphoid tissue of rats was determined by reversed phase high performance liquid chromatography after intraperitoneal injection of 5-FU carbon nanoparticle and 5-FU ordinary form(20 mg/kg body weight). Results 5-FU concentration of lymphoid tissue in the 5-FU carbon nanoparticle group was higher than that in the 5-FU ordinary form group,and could sustain a longer time. Conclus... |
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| Keywords: | Fluorouracil Carbon nanoparticle Lymphatic targeting |
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