环氧合酶-2和基质金属蛋白酶-9在宫颈癌中的表达及其临床意义

Objective： To investigate the expressions of cyclooxygenase （COX）-2 and matrix metalloproteinase （MMP）-9 in cervical carcinoma and their clinical significance. Methods： Immunohistochemistry SP method was used to detect the expressions of COX-2 and MMP-9 in 72 cases of invasive carcinoma of cervix （ICC） and 16 cases of normal cervical epithelium remote from tumor （NCE）. The relationships between the expressions of COX-2, MMP-9 in ICC and some characteristics relating to clinical pathology of cervical carcinoma such as histological grading, lymph node metastasis, stromal invasion and FIGO stage were analyzed statistically. Results： The rates of the positive expressions of COX-2 and MMP-9 in ICC were significantly higher than those in NCE. COX-2： 88.9% （64/72）in group ICC and 12.5% （2/16）in group NCE, P = 0.000; MMP-9： 94.4% （68/72） in group ICC and 43.8% （7/16） in group NCE, P = 0.000. The expression of COX-2 was positively correlated with lymph node metastasis （r= 0.296, P = 0.012） and stromal invasion （r = 0.257, P = 0.029）. The expression of MMP-9 was positively correlated with FIGO stage （r = 0.329, P = 0.005） and histological grading （r = 0.351, P = 0.003）. The expression of COX-2 was positively correlated with the expression of MMP-9 in ICC （r=0.297, P = 0.011）. Conclusion： The overexpressions of COX-2 and MMP-9 were closely related to the invasion and growth of cervical carcinoma. The tissue with the overexpression of COX-2 had strong invasion ability. COX-2 and MMP-9 had synergistic effect on proliferation, invasion and metastasis of cancer cells. Detecting the coexpression of COX-2 and MMP-9 may be of value in further understanding the biological behavior and predicting the prognosis of cervical carcinoma.

Expressions of cyclooxygenase-2 and matrix metalloproteinase-9 in cervical carcinoma and their clinical significance

Objective:To investigate the expressions of cyclooxygenase (COX)-2 and matrix metalloproteinase (MMP)-9 in cervical carcinoma and their clinical significance. Methods: Immunohistochemistry SP method was used to detect the expressions of COX-2 and MMP-9 in 72 cases of invasive carcinoma of cervix (ICC) and 16 cases of normal cervical epithelium remote from tumor (NCE). The relationships between the expressions of COX-2, MMP-9 in ICC and some characteristics relating to clinical pathology of cervical carcinoma such as histological grading, lymph node metastasis, stromal invasion and FIGO stage were analyzed statistically. Results: The rates of the positive expressions of COX-2 and MMP-9 in ICC were significantly higher than those in NCE. COX-2: 88.9% (64/72) in group ICC and 12.5% (2/16) in group NCE, P = 0.000;MMP-9: 94.4% (68/72) in group ICC and 43.8% (7/16) in group NCE, P = 0.000. The expression of COX-2 was positively correlated with lymph node metastasis (r = 0.296, P = 0.012) and stromal invasion (r= 0.257, P = 0.029). The expression of MMP-9 was positively correlated with FIGO stage (r = 0.329, P = 0.005) and histological grading (r = 0.351, P = 0.003). The expression of COX-2 was positively correlated with the expression of MMP-9 in ICC (r = 0.297, P = 0.011). Conclusion: The overexpressions of COX-2 and MMP-9 were closely related to the invasion and growth of cervical carcinoma. The tissue with the overexpression of COX-2 had strong invasion ability. COX-2 and MMP-9 had synergistic effect on proliferation, invasion and metastasis of cancer cells. Detecting the coexpression of COX-2 and MMP-9 may be of value in further understanding the biological behavior and predicting the prognosis of cervical carcinoma.