女性年龄与体外受精胚胎移植结果的关系

目的　探讨女性年龄与体外受精 胚胎移植结果的关系。方法　分析IVF ET 10 6个起始周期、90个移植周期的临床资料 ,按女性年龄≤ 30岁 ,31～ 34岁 ,≥ 35岁分Ⅰ ,Ⅱ ,Ⅲ组 ,比较取消率、Gn用量、卵泡数、回收卵子数、受精数、卵裂数、优质胚胎数、受精率、卵裂率、优质胚胎率及临床妊娠率的差别。结果　 3组的取消率分别为 12 .5 0 % ,2 .78% ,33 .33 % ,三组间相比差异显著 (P <0 .0 5 ) ;Gn用量分别为 (2 8.71± 5 .45 )支、(33 .46± 7.5 1)支、(34.0 5± 5 .78)支 ,3组相比 ,Ⅰ组与Ⅱ ,Ⅲ组差异显著 (P <0 .0 5 ) ,Ⅱ组与Ⅲ组之间差异不显著 (P >0 .0 5 ) ;各组间卵泡数、周期取卵数、受精数、卵裂数、优质胚胎数无显著性差异 (P >0 .0 5 ) ;3组受精率分别为 74.49% ,6 8.0 7% ,6 7.82 % ,各组间相比 ,Ⅰ组与Ⅱ ,Ⅲ组差异显著 (P <0 .0 5 ) ,Ⅱ组与Ⅲ组间差异不显著 (P >0 .0 5 ) ;而卵裂率、优质胚胎率无显著性差异 (P >0 .0 5 ) ;3组的每移植周期妊娠率分别是 45 .71% ,2 5 .71% ,15 .0 0 % ,各组间相比差异显著 (P <0 .0 5 )。结论　女性年龄是影响IVF ET成功的重要因素

Relationship Between Female Age and Results of in Vitro Fertlization Embryo Transfer

Objective To explore the association between female age and the outcome of IVF ET. Methods 106 initiated cycles and 90 embryo transfer cycles were divided into three groups by female age (≤30,31～34,≥35 years old). The results of three groups were compared with the number of follicles, oocytes recovered and fertilization, embryo number, high quality embryo number, insemination rate, clearage rate, rate of high quality embryo, number of embryos transferred, pregnancy rate. Results The rate of cancel cycles of three groups were 12.50%, 2.78% and 33.3% respectively. There was a signifficant differemce ( P <0.05). The number of Gn was 28.71±5.45, 33.46±7.51 and 34.05±5.78 respectively. There was a signifficant differemce, too. The number of follicles, oocytes recovered, fertilization, embryo number, high quality embryo number, number of embryos transferred hasn't signifficant difference. Signifficant differemce was found in insemination rate (74.49%, 68.07%, 67.20%). Cleavage rate and the rate of high quality embryo hasn't signifficant difference. The clinical pregnancy rate of per ET cycles was 45.71%, 25.71% and 15.00%. There was a signifficant differemce. Conclusion Female age has an important effect on success of IVF ET.