布地奈德联合氨溴索雾化吸入治疗新生儿吸入性肺炎疗效观察

目的:观察布地奈德联合氨溴索雾化吸入治疗新生儿吸入性肺炎疗效。方法:将收治的51例新生儿吸入性肺炎随机分成2组,观察组31例,对照组20例。治疗组在常规保持呼吸道通畅、保暖、氧疗、抗感染、支持治疗的同时加用布地奈德和氨溴索雾化吸入,观察2组临床症状和体征消失时间及平均住院时间。结果:观察组总有效率90.3%,明显高于对照组55.0%(P0.01);口吐泡沫、呼吸困难、口周紫绀及肺部啰音消失时间均快于对照组,住院时间较对照组缩短(P0.05～P﹤0.01)。结论:布地奈德联合氨溴索雾化吸入辅助治疗新生儿吸入性肺炎,能明显改善新生儿吸入性肺炎临床症状,缩短住院时间,临床应用安全、有效。

Effect of budesonide combined with ambroxol hydrochloride on newborns with aspiration pneumonia

Objective:To investigate the clinical effects of budesonide combined with ambroxol hydrochloride in treatment of newborns with aspiration pneumonia.Methods:Fifty-one cases of newborns with aspiration pneumonia were randomly divided into observation group(31 cases) and control group(20 cases).Both groups received the routine therapies including warm-keeping,keeping the airway unobstructed,use of antibiotics and oxygen,and support procedures.The patients in observation group were administered aerosol inhalation of budesonide combined with ambroxol hydrochloride in addition.The clinical symptoms and the average hospital stay of the two groups were observed.Results:The total effective rate was 90.3% and 55.0% in the observation group and the control group respectively.The difference between the two groups was remarkable(P<0.01);the duration of frothing at lips,dyspnea,cyanosis,rale and hospital stay of the observation group was significantly shorter than that of the control group(P<0.05 to P<0.01).Conclusions:Aerosol inhalation of budesonide combined with ambroxol hydrochloride can obviously improve the clinical symptoms and cut down the hospital stay of the newborns with aspiration pneumonia.It is a safe and effective therapy.