含氟酪蛋白磷酸肽—磷酸钙复合物对酸蚀牙釉质显微硬度的影响

目的研究含氟酪蛋白磷酸肽-磷酸钙复合物(CPP-ACP)在体外对酸蚀牛牙釉质显微硬度的影响。方法选择新鲜拔除的牛下切牙60个,制成60个5mm×5mm正方形釉质开窗区,其余部分由抗酸指甲油涂抹封闭,将釉质块样本完全随机分为4组,每组15个,分别进行4种不同处理(A组为阴性对照组;B组为阳性对照组,使用碳酸饮料酸蚀处理;C组为碳酸饮料酸蚀后使用CPP-ACP进行再矿化;D组为酸蚀后使用含氟CPP-ACP(氟浓度为900ppm)再矿化。使用显微硬度仪测定样本显微硬度,比较各组显微硬度的差别。结果 D组显微硬度较C组高,C组及D组显微硬度均高于B组但低于A组,各组间的差异具有统计学意义(P0.01)。结论含氟酪蛋白磷酸肽-磷酸钙复合物可以提高酸蚀牙釉质的显微硬度。

Effect of casein phosphopeptide-amorphous calcium phosphate with fluoride on microhardness of erosived enamel

Objective To evaluate the effect of casein phosphopeptide-amorphous calcium phosphate(CPP-ACP) with fluoride on microhardness of erosive enamel.Methods Sixty fresh bovine lower incisors were selected,then enamel window of 5mm×5mm was made on each of them,and other area was sealed with nail polisher.The samples were stratified and allocated to 4 groups(A-D).Samples in group A remained untreated and served as negative control;group B treated with coke,group C renimeralized with CPP-ACP after erosion;group D renimeralized by CPP-ACP with fluoride after erosion.Samples′ microhardness was measured to compare the difference.Results The microhardness of group D was significantly higher than that of group C and group D,and group C was higher than that of group B but lower than group A.There was significant difference among all groups(P<0.01).Conclusion The microhardness of erosived enamel can be increased by casein phosphopeptide-amorphous calcium phosphate with fluoride.