| 去铁胺对小鼠糖尿病随意型皮瓣成活影响研究 |
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| 引用本文： | 蔡源源,崔磊,李光早.去铁胺对小鼠糖尿病随意型皮瓣成活影响研究[J].蚌埠医学院学报,2012,37(1):14-16. |
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| 作者姓名： | 蔡源源 崔磊 李光早 |
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| 作者单位： | 蚌埠医学院第一附属医院,整形外科,组织移植安徽省重点实验室,安徽,蚌埠,233004;上海组织工程研究与开发中心,上海,200235 |
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| 摘 要： | 目的:观察去铁胺(DFO)对小鼠糖尿病随意性皮瓣成活面积的影响。方法:C57/BL6小黑鼠被链脲佐菌素诱导成糖尿病后,在其背部制成1 cm×3 cm随意性皮瓣,将DFO用PBS溶解后,腹腔注射,通过图像分析技术和激光多普勒分析皮瓣的成活率和血流状况。结果:DFO组皮瓣的存活面积(88.44±6.56)%明显大于PBS介质组(61.64±7.63)%(P0.01)。激光多普勒结果显示,DFO处理组皮瓣各部分血流值均大于PBS组(P0.01)。结论:DFO能够增加糖尿病C57/BL6小鼠背部随意皮瓣的血流量和存活面积。
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| 关 键 词： | 糖尿病 皮瓣 去铁胺 小鼠 |
Investigation of the influence of deferoxamine on the survival of a random pattern skin flap in diabetic mice |
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| CAI Yuan-yuan,CUI Lei,LI Guang-zao.Investigation of the influence of deferoxamine on the survival of a random pattern skin flap in diabetic mice[J].Journal of Bengbu Medical College,2012,37(1):14-16. |
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| Authors: | CAI Yuan-yuan CUI Lei LI Guang-zao |
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| Institution: | 1(1.Department of Plastic Surgery,The First Affiliated Hospital of Bengbu Medical College, Anhui Key Laboratory of Tissue Transplantation,Bengbu Anhui 233004; 2.Tissue Engineering Research and Development in Shanghai,Shanghai 200235,China) |
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| Abstract: | Objective:To investigate the influence of deferoxamine(DFO) on the survival of random pattern skin flap in diabetic mice.Methods:Diabetes mellitus was induced with streptozotocin in C57/BL6 mice.Α random pattern skin flap(1 cm×3 cm) was cranially designed and elevated on the back of C57/BL6 mice.An image analysis technology was used to evaluate the survival rate of the skip flap and laser Doppler was used to survey the blood perfusion situation of skin flap.Results:Compared with control group(61.64±7.63)%,the survival area of the flap in DFO group was(88.44±6.56)%,which was significantly enlarged in seven days postoperatively(P<0.01).Laser Doppler results displayed the blood flow in DFO group was higher than in control group(P<0.01).Conclusions:DFO could improve flap microcirculation and increase its survival rate. |
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| Keywords: | diabetes mellitus skin flap deferoxamine mice |
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