Genetic characterization of Pseudomonas aeruginosa bacteriophage KPP10 |
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| Authors: | Uchiyama Jumpei Rashel Mohammad Takemura Iyo Kato Shin-Ichiro Ujihara Takako Muraoka Asako Matsuzaki Shigenobu Daibata Masanori |
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| Affiliation: | (1) Department of Microbiology and Infection, Faculty of Medicine, Kochi University, Kohasu, Oko-cho, Nankoku Kochi, 783-8505, Japan;(2) Research Institute of Molecular Genetics, Kochi University, Nankoku Kochi, 783-8502, Japan;(3) Science Research Center, Kochi University, Kohasu, Oko-cho, Nankoku Kochi, 783-8505, Japan;(4) Kochi Gakuen College, Kochi Kochi, 780-0955, Japan; |
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| Abstract: | ![]()
Bacteriophage (phage) KPP10 has been used in experimental phage therapies directed against P. aeruginosa infections. To examine the eligibility of phage KPP10 as a therapeutic phage, its genome was analyzed. The genomic DNA was shown to be 88,322 bp long, with 158 open reading frames (ORFs), and three tRNA genes were predicted. No ORF-encoded pathogenicity or lysogenization factor was predicted. A comparative genomic analysis revealed that phage KPP10, together with phage PAK_P3, can be grouped as a new type of lytic phage infecting P. aeruginosa. Phage KPP10 is considered to be suitable for therapeutic purposes because it is a lytic phage without ORF-encoded pathogenicity or a lysogenization factors. |
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