| 三七参泰胶囊对小鼠急性化学性肝损伤的保护作用 |
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| 引用本文： | 王朝梁,柯金虎,范嘉洪,崔秀明. 三七参泰胶囊对小鼠急性化学性肝损伤的保护作用[J]. 中成药, 2004, 26(11): 922-924 |
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| 作者姓名： | 王朝梁 柯金虎 范嘉洪 崔秀明 |
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| 作者单位： | 1. 文山州三七科学技术研究所,云南,文山,663000
2. 文山赛参生物科技有限公司,云南,文山,663000 |
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| 摘 要： | 目的:观察三七参泰胶囊(三七、茵陈、大枣等)的保肝作用.方法:采用腹腔注射四氯化碳(CCl4)致小鼠肝脏损伤为模型,测定低、中、高剂量的三七参泰胶囊对肝损伤ALT、AST等生化指标的影响,同时对肝组织进行病理组织学检查.结果:三七参泰胶囊各剂量组均能显著降低CCl4肝损伤所致的小鼠血清丙氨酸氨基转移酶(ALT)升高(P＜0.01)及天门冬氨酸氨基转移酶(AST)升高(P＜0.01),减轻CCl4对肝脏细胞的病理损伤.结论:三七参泰胶囊对小鼠急性化学性肝损伤具有明显的保护作用.
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| 关 键 词： | 三七参泰胶囊 急性化学性肝损伤 四氯化碳 |
| 文章编号： | 1001-1528(2004)11-0922-03 |
Protection of Sanqibaogan Capsules against the acute and chemical liver injury in mice |
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| WANG Chao liang ,KE Jin hu ,FAN Jia hong ,CUI Xiu ming. Protection of Sanqibaogan Capsules against the acute and chemical liver injury in mice[J]. Chinese Traditional Patent Medicine, 2004, 26(11): 922-924 |
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| Authors: | WANG Chao liang KE Jin hu FAN Jia hong CUI Xiu ming |
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| Affiliation: | WANG Chao liang 1,KE Jin hu 1,FAN Jia hong 2,CUI Xiu ming 1 |
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| Abstract: | AIM: To observe the liver protective effect of Sanqishentai Capsules (Radix Notoginseng, Herba Artemisiae Scopariae and Fructus Ziziph:Jujubae, etc.) in order to develop a series of compound Notoginseng. METHODS: By injecting CCl 4 in mouse's abdomen to cause the liver injury as model. The effect of the index of ALT, AST was mensurated that use the small, middle, big dosage of Sanqibaogan Capsules, at the same time the liver was examined in pathologic histology. RESULTS: The different dosages of Sanqishentai Capsules could obviously reduce the serum ALT, AST and the pathologic injury of the liver cells caused by CCl 4. CONCLUSION: Sanqibaogan Capsules have the obvious protection to the ocute and chemical liver injury of the mice. |
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| Keywords: | Sanqibaogan Capsules acute and chemical liver injury CCl-4 |
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