内皮素-1与基质金属蛋白酶-9在喉癌中的表达与临床病理特征的相关性研究

目的:探讨内皮素-1(ET-1)和基质金属蛋白酶-9(MMP-9)在喉癌中的表达情况及其与临床病理特征之间的相互关系。方法:采用免疫组织化学SP法检测58例喉癌、28例声带息肉及19例喉部正常黏膜组织中ET-1、MMP-9的表达。结果:喉癌组织中ET-1的表达率为81.03%(47/58),与声带息肉(57.14%)和喉部正常黏膜组织(57.89%)对比,差异有统计学意义(P<0.05)。MMP-9在喉癌中的表达率为72.41%(42/58),与声带息肉(50.00%)和喉部正常黏膜组织(47.37%)对比,差异有统计学差异(P<0.05)。ET-1、MMP-9的表达与喉癌的临床分期、浸润深度及有无淋巴结转移均有一定关系。结论:ET-1与MMP-9的高表达可能与喉癌的发生、发展关系密切,可为喉癌的靶向及个性化治疗策略提供一定的理论依据。

Significance expression and relationships with endothelin-1, matrix metalloproteinase-9 in the laryngeal carcinoma

Objective:To evaluate the expression of endothelin-1(ET-1) and matrix metalloproteinase-9(MMP-9) in laryngeal carcinoma and their correlations with clinical features.Method:The expression of ET-1 and MMP-9 was detected by immunohistochemical method in 58 specimens of laryngeal carcinoma,28 specimens of polyps of vocal cord and 19 specimens of normal laryngeal tissues.Result:The expressions of ET-1,MMP-9 in laryngeal carcinoma were remarkably higher,compared to polyps of vocal cord and normal laryngeal tissues(P<0.05).The expression of ET-1,MMP-9 was associated with clinical stage,T stage and lymph node metastasis.Expression levels of ET-1and MMP-9 correlated significantly with each other(rs=0.693,P<0.05).Conclusion:The expression of ET-1 and MMP-9 may be the vital indexes in laryngeal carcinoma.