中药注射液防治心肌缺血再灌注损伤的研究进展

目的 介绍中药注射液防治心肌缺血再灌注损伤的研究进展.方法 根据近年的研究文献,总结中药注射液防治心肌缺血再灌注损伤方面的研究及作用机理.结果 川芎嗪注射液、红花注射液、葛根素注射液、生脉注射液、母草注射液、血塞通注射液、参附注射液具有抗心肌缺血再灌注损伤作用.作用机理包括抗氧自由基损伤、抑制细胞凋亡、心肌保护、抑制炎症及抑制心肌缺血再灌注损伤时的钙超载等.结论 中药注射液防治心肌缺血再灌注损伤作用肯定,应用前景广阔.

Progress in Prevention and Treatment of Myocardial lschemia Reperfusion with Traditional Chinese Herbal Injection

Objective To introduce the curative effect of traditional Chinese herbal parenteral solution in prevention and cure of myocardial ischemia reperfusion. Methods To summarize the recent progress in literature on treatment of myocardial ischemia reperfusion with traditional Chinese herbal injection. Results Chuanxiongzine injection, Carthami injection, Puerarin Injection, Pulse-activating injection, Brittle falsepimpernel herb injection, Xuesaitong injection, and Canfu injection have the function of treating myocardial ischemia reperfusion. The therapeutic mechanisms of these injections included protecting against oxygen-derived free radical damage, inhibiting cadiocyte apoptosis, preserving cardic muscle, and inhibiting inflammation and calcium overload in the process of reperfusion. Conclusion Chinese herbal parenteral solution has a substantial curative effect in treating myocardial ischemia reperfusion.