COVID-19 and liver dysfunction: A systematic review and meta-analysis of retrospective studies |
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| Authors: | Mohanad Youssef Mohammad H Hussein Abdallah S Attia Rami M Elshazli Mahmoud Omar Ghassan Zora Ashraf S Farhoud Ahmad Elnahla Areej Shihabi Eman A Toraih Manal S Fawzy Emad Kandil MD MBA FACS FACE |
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| Affiliation: | 1. Department of Surgery, Tulane University, School of Medicine, New Orleans, Louisiana;2. Department of Biochemistry and Molecular Genetics, Faculty of Physical Therapy, Horus University—Egypt, New Damietta, Egypt;3. Department of Medical Biochemistry and Molecular Biology, Faculty of Medicine, Suez Canal University, Ismailia, Egypt;4. Division of Endocrine and Oncologic Surgery, Department of Surgery, Tulane University, School of Medicine, New Orleans, Louisiana |
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| Abstract: | ![]()
Recently, Coronavirus Disease 2019 (COVID-19) pandemic is the most significant global health crisis. In this study, we conducted a meta-analysis to find the association between liver injuries and the severity of COVID-19 disease. Online databases, including PubMed, Web of Science, Scopus, and Science direct, were searched to detect relevant publications up to 16 April 2020. Depending on the heterogeneity between studies, a fixed- or random-effects model was applied to pool data. Publication bias Egger's test was also performed. Meta-analysis of 20 retrospective studies (3428 patients), identified that patients with a severe manifestation of COVID-19 exhibited significantly higher levels of alanine aminotransferase, aspartate aminotransferase, and bilirubin values with prolonged prothrombin time. Furthermore, lower albumin level was associated with a severe presentation of COVID-19. Liver dysfunction was associated with a severe outcome of COVID-19 disease. Close monitoring of the occurrence of liver dysfunction is beneficial in early warning of unfavorable outcomes. |
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| Keywords: | COVID-19 liver function meta-analysis outcome SARS-CoV-2 |
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