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| 兔不稳定斑块的18F-FDG PET/CT显像及其病理学检测 | |
| 引用本文： | 张丹丹,徐占民,宋爱丽,赵全明,董小黎. 兔不稳定斑块的18F-FDG PET/CT显像及其病理学检测[J]. 基础医学与临床, 2010, 30(1): 33-36 |
| 作者姓名： | 张丹丹 徐占民 宋爱丽 赵全明 董小黎 |
| 作者单位： | 1. 首都医科大学,基础医学院病理教研室,北京,100069 2. 首都医科大学,附属安贞医院心内科,北京,100029 |
| 基金项目： | 北京市教委基金(KM200710025006) |
| 摘 要： | 目的 探讨氟18标记的脱氧葡萄糖 (18F-FDG) PET/CT无创检测不稳定斑块的可行性。方法 用新西兰雄性大白兔建立动脉粥样硬化模型，注射18F-FDG后行腹主动脉PET/CT成像,离体动脉数码照相,测定动脉片段的放射强度，选取不稳定和稳定斑块各30块，比较其放射强度，采用免疫组化方法观察斑块中的巨噬细胞和平滑肌细胞并计数。结果 PET/CT活体成像可见实验组沿腹主动脉走行的不均匀的放射性分布，与离体动脉的斑块分布基本一致；不稳定斑块组的靶-非靶比值和巨噬细胞数明显高于稳定斑块组(P＜0.01)，而平滑肌细胞数明显降低(P＜0.01)；靶-非靶比值与斑块中的巨噬细胞数呈正相关(r=0.815，P＜0.01),而与平滑肌细胞数呈负相关(r=-0.684，P＜0.01)。结论18F-FDG PET/CT无创检测实验性不稳定斑块具有一定的可行性。 |
| 关 键 词： | 18F-FDG PET/CT 不稳定斑块 巨噬细胞 平滑肌细胞 |
| 收稿时间： | 2008-12-25 |
| 修稿时间： | 2009-05-11 |
Profile of pathology in rabbit unstable plaque with ~(18)F-FDG PET/CT detection |
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| ZHANG Dan-dan,XU Zhan-min,SONG Ai-li,ZHAO Quan-ming,DONG Xiao-li. Profile of pathology in rabbit unstable plaque with ~(18)F-FDG PET/CT detection[J]. Basic Medical Sciences and Clinics, 2010, 30(1): 33-36 | |
| Authors: | ZHANG Dan-dan XU Zhan-min SONG Ai-li ZHAO Quan-ming DONG Xiao-li |
| Affiliation: | 1.Department of Pathology;Basic Medical College of Capital Medical University;Beijing 100069;2.Department of Cardiology;Anzhen Hospital Affiliated to Capital Medical University;Beijing 100029;China |
| Abstract: | Objective To study the feasibility of noninvasive detection of unstable plaques with 18F-Fluorodeoxyglucose (18F-FDG) PET/CT imaging. Methods Atherosclerotic plaques were induced in male New Zealand white rabbits. Animals were injected with FDG labeled with 18F,then examined with PET/CT. Aorta was explanted for photography with digital camera,and 18F-FDG uptake analysis. Thirty unstable plaques and 30 stable plaques were choosed so as to compare the quantitativly 18F-FDG uptake.The number of macrophages and... |
| Keywords: | 18F-FDG PET/CT unstable plaque macrophage smooth muscle cell |
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