|
|||||
|
|
Fetal and maternal plasma homocysteine levels during the second half of uncomplicated pregnancy |
|
| Authors: | Nebojsa Radunovic Charles J. Lockwood Olivera Stanojlovic Milena Steric Olivera Kontic-Vucinic Nenad Sulovic |
| Affiliation: | 1. Faculty of Medicine, University of Belgrade, Belgrade, Serbia and;2. Department of Obstetrics and Gynecology, The Ohio State University College of Medicine, Columbus, OH, USA |
| Abstract: | Objective: To measure fetal and maternal plasma homocysteine (Hcy) concentrations in uncomplicated pregnancies. Methods: Paired maternal venous and fetal umbilical cord blood (n?=?81) samples were evaluated for plasma Hcy and vitamin B12 levels, in addition to eight neonatal umbilical cord blood samples obtained immediately following delivery. Results: Both fetal and maternal Hcy concentrations were positively correlated with advancing gestational age (ρ?=?0.44, p?ρ?=?0.27, p?p?p?p?=?0.016]. Significant correlation was noted and between fetal and maternal Hcy levels (ρ?=?0.50, p?12 concentrations (ρ?=??0.32, p? Conclusions: Fetal Hcy levels were significantly lower than maternal and neonatal levels and correlated with gestational age across the second half of pregnancy. |
| Keywords: | Fetal blood homocysteine maternal blood vitamin B12 |