Inhibition of cyclo-oxygenase-2 expression in mouse macrophages by 4-(3-methyl-but-1-enyl)-3,5,3',4'-tetrahydroxystilbene, a resveratrol derivative from peanuts

Resveratrol derivatives are of interest as inhibitors of cyclo-oxygenase-2 and as antiinflammatory agents. The prenylated resveratrol derivative 4-(3-methyl-but-1-enyl)-3,5,3',4'-tetrahydroxystilbene was purified from fungally infected peanuts by thin layer chromatography and its structure was confirmed by mass spectrometry. 4-(3-Methyl-but-1-enyl)-3,5,3',4'-tetrahydroxystilbene inhibited lipopolysaccharide-induced expression of cyclo-oxygenase-2 protein and cyclo-oxygenase-2 mRNA in mouse macrophages at concentrations that were non-cytotoxic. 4-(3-Methyl-but-1-enyl)-3,5,3',4'-tetrahydroxystilbene warrants further evaluation as an antiinflammatory agent.