The “graft versus leukemia” effect under conditions of mixed chimeric hemopoiesis |
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| Authors: | G. V. Seledtsova V. I. Seledtsov I. V. Avdeev D. M. Samarin V. A. Kozlov |
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| Affiliation: | (1) Institute of Clinical Immunology, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk |
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| Abstract: | The “graft versus leukemia” effect can be induced in (C57B1/6×DBA) F1 mice by two transplantations of cell suspensions containing bone marrow cells and splenocytes of (CBA×C57B1/6) F1 mice and an injection of cyclophosphamide. The recipients of cell allotransplants were characterized by mixed chimeric hemopoiesis. These data outline a new approach to induction of the graft versus leukemia effect, requiring no complete elimination of the recipient's hemopoiesis and characterized by a low probability of lethal graft-versus-host reaction. Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 123, No. 5, pp. 562–565, May, 1997 |
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| Keywords: | mixed chimeric hemopoiesis graft versus leukemia effect |
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