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High microvessel density in pancreatic ductal adenocarcinoma is associated with high grade
Authors:Anca Barău  Amparo Ruiz-Sauri  Gerardo Valencia  Maria del Carmen Gómez-Mateo  Luis Sabater  Antonio Ferrandez  Antonio Llombart-Bosch
Affiliation:1. Department of Internal Medicine, Emergency County Hospital Craiova, University of Medicine and Pharmacy Craiova, Petru Rare? 2, Craiova, 200349, Romania
2. Department of Pathology, University of Valencia, Valencia, Spain
3. Department of Surgery, Hospital Clinico Universitario de Valencia, Valencia, Spain
Abstract:The objectives of this work are to study angiogenesis in pancreatic ductal adenocarcinoma using computerized morphometric and image analysis and to compare the microvascular density in intratumoral and peritumoral areas and normal pancreatic tissue. Microvascular density was analyzed in 60 cases of pancreatic ductal adenocarcinoma and 30 samples of normal pancreatic tissue using an avidin–biotin immunoperoxidase technique with an anti-CD31 antibody. Microvascular density (MVD) was analyzed through digital microimaging and computerized analysis. The blood vessel density in the tumor was significantly higher than in peritumoral areas and in normal pancreatic tissue. Well differentiated pancreatic ductal adenocarcinomas contained higher MVD than poorly differentiated carcinomas. In pancreatic adenocarcinoma, MVD is higher than in peritumoral tissue or normal pancreatic tissue.
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